Montan S, Liedholm H, Lingman G, Marsál K, Sjöberg N O, Solum T
Br J Obstet Gynaecol. 1987 Apr;94(4):312-7. doi: 10.1111/j.1471-0528.1987.tb03097.x.
Fetal circulation was studied by means of combined real-time and pulsed Doppler ultrasound in 14 women with pregnancy-associated hypertension before and during the first and third days of treatment with the beta 1-selective blocker, atenolol; in seven of the women the maternal uterine arcuate blood velocity waveform was also studied. Blood flow characteristics were normal both in the fetus and in the maternal arcuate artery, compared with those in uncomplicated pregnancies of corresponding gestational ages. Volume blood flow remained unchanged in the fetal descending aorta, and in the umbilical vein during atenolol treatment, whereas the pulsatility index increased in the fetal descending aorta and in the arcuate artery. This suggests that the peripheral vascular resistance, both on the maternal and fetal side of the placenta, increased during short-term antihypertensive treatment with atenolol.
采用实时和脉冲多普勒超声联合技术，对14例妊娠高血压综合征妇女在使用β1选择性阻滞剂阿替洛尔治疗前、治疗第1天和第3天期间的胎儿循环进行了研究；其中7例妇女还研究了其子宫弓状动脉的血流速度波形。与相应孕周的正常妊娠相比，胎儿及母体弓状动脉的血流特征均正常。在阿替洛尔治疗期间，胎儿降主动脉和脐静脉的血流量保持不变，而胎儿降主动脉和弓状动脉的搏动指数增加。这表明，在使用阿替洛尔进行短期降压治疗期间，胎盘母体侧和胎儿侧的外周血管阻力均增加。
