Kromann-Andersen B, Walter S, Jakobsen H, Vejlsgaard R
Dan Med Bull. 1987 Jun;34(3):182-3.
A prospective study compared the detection of leucocytes and bacteria in urine with the dipstick test (presence of esterases in granulocytes and nitrite) to chamber counting of urine, microscopic examination of the urinary sediment, and urine culture. Examined were 174 urine specimens. The dipstick esterase test and the sediment count were almost equally sensitive in detecting leucocyturia. Using chamber count and a cut-off point of 10 or more leucocytes per cubic millimeter as denoting significant leucocyturia, the esterase test gave a predictive value for negative test (PV neg) of 75% and a predictive value for positive test (PV pos) of 96%. PV neg of the dipstick nitrite test was 78% and PV pos 100% in detecting bacteriuria (10(5) bacteria per milliliter). Combining the esterase test with the nitrite test did not increase PV neg. Our result was that the dipstick test seems to be a simple screening procedure for leucocyturia and bacteriuria. The test is suggested to replace the time-consuming microscopic examinations of urine for leucocytes. When the nitrite test is positive, routine urine culture may be omitted.
一项前瞻性研究将尿液试纸检测（粒细胞中酯酶的存在和亚硝酸盐）与尿液计数板计数、尿沉渣显微镜检查及尿培养进行比较，以检测尿液中的白细胞和细菌。共检测了174份尿液标本。试纸酯酶检测和沉渣计数在检测白细胞尿方面的敏感性几乎相同。以计数板计数且每立方毫米10个或更多白细胞作为显著白细胞尿的判定标准时，酯酶检测的阴性预测值（PV neg）为75%，阳性预测值（PV pos）为96%。在检测菌尿（每毫升10⁵个细菌）时，试纸亚硝酸盐检测的PV neg为78%，PV pos为100%。将酯酶检测与亚硝酸盐检测相结合并未提高PV neg。我们的结果是，试纸检测似乎是一种用于白细胞尿和菌尿的简单筛查方法。建议该检测取代耗时的尿白细胞显微镜检查。当亚硝酸盐检测呈阳性时，可省略常规尿培养。
