细胞色素 P450 酶在药理学和毒理学中的作用：过去、现在和未来。
Roles of cytochrome P450 enzymes in pharmacology and toxicology: Past, present, and future.
机构信息
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, United States.
出版信息
Adv Pharmacol. 2022;95:1-47. doi: 10.1016/bs.apha.2021.12.001. Epub 2022 Jul 18.
Abstract
The development of the cytochrome P450 (P450) field has been remarkable in the areas of pharmacology and toxicology, particularly in drug development. Today it is possible to use the knowledge base and relatively straightforward assays to make intelligent predictions about drug disposition prior to human dosing. Much is known about the structures, regulation, chemistry of catalysis, and the substrate and inhibitor specificity of human P450s. Many aspects of drug-drug interactions and side effects can be understood in terms of P450s. This knowledge has also been useful in pharmacy practice, as well as in the pharmaceutical industry and medical practice. However, there are still basic and practical questions to address regarding P450s and their roles in pharmacology and toxicology. Another aspect is the discovery of drugs that inhibit P450 to treat diseases.
摘要
细胞色素 P450（P450）领域在药理学和毒理学领域的发展引人注目，特别是在药物开发方面。如今，人们可以利用知识库和相对简单的检测方法，在对人体进行给药之前，对药物的处置情况做出明智的预测。人们对人类 P450 的结构、调节、催化化学以及底物和抑制剂特异性有了很多了解。许多药物相互作用和副作用方面的问题都可以从 P450 的角度来理解。这方面的知识在药学实践、制药工业和医疗实践中也很有用。然而，在 P450 及其在药理学和毒理学中的作用方面，仍然存在一些基础性和实践性的问题需要解决。另一方面是发现抑制 P450 的药物来治疗疾病。
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