Ekundayo Temitope C, Igere Bright E, Iwu Chidozie D, Oluwafemi Yinka D, Tiamiyu Adebisi M, Adesina Isaac A, Anuoluwa Iyadunni A, Ekundayo Esther A, Bello Olorunjuwon O, Olaniyi Oladipo O, Ijabadeniyi Oluwatosin A
Department of Biotechnology and Food Science, Durban University of Technology, Steve Biko Campus, Health Services, 121 Steve Biko Rd, Musgrave, Berea, 4001, Durban, South Africa; Department of Biological Sciences, University of Medical Sciences, Ondo City, Ondo State, Nigeria.
Department of Microbiology and Biotechnology, Western Delta University, Oghara, Delta State, Nigeria.
Food Microbiol. 2022 Oct;107:104089. doi: 10.1016/j.fm.2022.104089. Epub 2022 Jul 9.
Laribacter hongkongensis is a human pathogen harboured in food and environmental matrices. This present study aimed to meta-analysed the prevalence of L. hongkongensis in humans, aquatic products, food/non-food animals, and environmental waters to provide update information on the pathogen. Nine electronic databases were systematically searched for articles on L. hongkongensis and a random-effects-model meta-analysis on its prevalence was conducted. Assessment of heterogeneities and publication biases across the studies was determined by using the I statistic and Egger's regression/rank correlation tests of funnel plot, respectively. Furthermore, a meta-regression model was explored to unravel factors influencing the prevalence. A total of 39 documents were identified, of which, 33 articles were included as 98 sub-studies for the meta-analysis, and 87 sub-studies for subgroup-analysis. Overall, the prevalence of L. hongkongesis in human, aquatic products, food/non-food animals, and environmental waters was 8.5% (95% CI: 5.8-11.7). The leave-one-out influence analysis yielded a pooled prevalence of L. hongkongensis ranging from 8.1% (95% CI: 5.4-11.3) - 8.8% (95% CI: 5.8-12.3). Sub-group analysis found that the prevalence of L. hongkongensis was highest in Amphibian (54.6%, 95% CI: 41.3-67.6), followed by Pisces (7.9%, 95% CI: 5.3-10.9), Avian (0.5%, 95% CI: 0-5.8), and Mammal (0.5%, 95% CI: 0-3.6). In addition, Egger's regression-test of funnel plot suggests presence of publication (z = 4.2, p < 0.0001) in mammal subgroup. Multivariate meta-regression showed that the prevalence was significantly influenced by source type, class, and identification/detection method with the source type, class, and detection method specifically accounted for 25.49%, 11.28%, and 3.84% of the heterogeneity, respectively. Conclusively, the prevalence of L. hongkongensis decrease in order of Amphibian (54.6%), Pisces (7.9%), Avian (0.5%) and Mammal (0.5%). Aquatic products and environments are essential sources of the pathogen.
香港拉氏菌是一种存在于食物和环境基质中的人类病原体。本研究旨在对香港拉氏菌在人类、水产品、食用/非食用动物及环境水体中的流行情况进行荟萃分析，以提供该病原体的最新信息。我们系统检索了九个电子数据库中关于香港拉氏菌的文章，并对其流行情况进行随机效应模型荟萃分析。分别使用I统计量和漏斗图的Egger回归/秩相关检验来评估研究间的异质性和发表偏倚。此外，还探索了一个荟萃回归模型以揭示影响流行率的因素。共识别出39篇文献，其中33篇文章被纳入荟萃分析，包含98项子研究，另有87项子研究用于亚组分析。总体而言，香港拉氏菌在人类、水产品、食用/非食用动物及环境水体中的流行率为8.5%（95%可信区间：5.8 - 11.7）。逐一剔除影响分析得出香港拉氏菌的合并流行率范围为8.1%（95%可信区间：5.4 - 11.3）至8.8%（95%可信区间：5.8 - 12.3）。亚组分析发现，香港拉氏菌在两栖动物中的流行率最高（54.6%，95%可信区间：41.3 - 67.6），其次是鱼类（7.9%，95%可信区间：5.3 - 10.9）、禽类（0.5%，95%可信区间：0 - 5.8）和哺乳动物（0.5%，95%可信区间：0 - 3.6）。此外，漏斗图的Egger回归检验表明哺乳动物亚组存在发表偏倚（z = 4.2，p < 0.0001）。多变量荟萃回归显示，流行率受来源类型、类别和鉴定/检测方法的显著影响，其中来源类型、类别和检测方法分别占异质性的25.49%、11.28%和3.84%。总之，香港拉氏菌的流行率按两栖动物（54.6%）、鱼类（7.9%）、禽类（0.5%）和哺乳动物（0.5%）的顺序递减。水产品和环境是该病原体的重要来源。
