Odeyemi Omowale A, Amin Muhamad, Dewi Fera R, Kasan Nor Azman, Onyeaka Helen, Stratev Deyan, Odeyemi Olumide A
Centre for Child & Adolescent Mental Health (CCAMH), University of Ibadan, Ibadan North, Nigeria.
School of Nursing, Obafemi Awolowo University Teaching Hospital Complex, Ile Ife, Nigeria.
Antibiotics (Basel). 2023 Apr 28;12(5):829. doi: 10.3390/antibiotics12050829.
The objective of this study was to examine the frequency and extent of antibiotic-resistant pathogens in seafood sold in Malaysia, using a systematic review and meta-analysis approach to analyze primary research studies. Four bibliographic databases were systematically searched for primary studies on occurrence. Meta-analysis using a random-effect model was used to understand the prevalence of antibiotic-resistant bacteria in retail seafood sold in Malaysia. A total of 1938 primary studies were initially identified, among which 13 met the inclusion criteria. In the included primary studies, a total of 2281 seafoods were analyzed for the presence of antibiotic-resistant seafood-borne pathogens. It was observed that 51% (1168/2281) of the seafood was contaminated with pathogens. Overall, the prevalence of antibiotic-resistant seafood-borne pathogens in retail seafood was 55.7% (95% CI: 0.46-0.65). Antibiotic-resistant species had an overall prevalence of 59.9% (95% CI: 0.32-0.82) in fish, species had an overall prevalence of 67.2% (95% CI: 0.22-0.94) in cephalopods, and MRSA had an overall prevalence of 70.9% (95% CI: 0.36-0.92) in mollusks. It could be concluded that there is a high prevalence of antibiotic-resistant seafood-borne pathogens in the retail seafood sold in Malaysia, which could be of public health importance. Therefore, there is a need for proactive steps to be taken by all stakeholders to reduce the widespread transmission of antibiotic-resistant pathogens from seafood to humans.
本研究的目的是通过系统评价和荟萃分析方法来分析原始研究，以检查马来西亚销售的海鲜中抗生素抗性病原体的频率和程度。系统检索了四个文献数据库，以查找关于发生率的原始研究。使用随机效应模型进行荟萃分析，以了解马来西亚零售海鲜中抗生素抗性细菌的流行情况。最初共识别出1938项原始研究，其中13项符合纳入标准。在纳入的原始研究中，共分析了2281份海鲜，以检测是否存在抗生素抗性的食源性病原体。结果发现，51%（1168/2281）的海鲜被病原体污染。总体而言，零售海鲜中抗生素抗性食源性病原体的流行率为55.7%（95%置信区间：0.46 - 0.65）。抗生素抗性物种在鱼类中的总体流行率为59.9%（95%置信区间：0.32 - 0.82），在头足类动物中的总体流行率为67.2%（95%置信区间：0.22 - 0.94），在软体动物中耐甲氧西林金黄色葡萄球菌（MRSA）的总体流行率为70.9%（95%置信区间：0.36 - 0.92）。可以得出结论，马来西亚销售的零售海鲜中抗生素抗性食源性病原体的流行率很高，这可能对公共卫生具有重要意义。因此，所有利益相关者都需要采取积极措施，以减少抗生素抗性病原体从海鲜向人类的广泛传播。
