Gasnier Matthieu, Choucha Walid, Radiguer Francois, Faulet Theo, Chappell Kenneth, Bougarel Aurore, Kondarjian Christian, Thorey Paul, Baldacci Antoine, Ballerini Maryne, Ait Tayeb Abd El Kader, Herrero Hugo, Hardy-Leger Isabelle, Meyrignac Olivier, Morin Luc, Lecoq Anne-Lise, Pham Tài, Noel Nicolas, Jollant Fabrice, Montani David, Monnet Xavier, Becquemont Laurent, Corruble Emmanuelle, Colle Romain
Service Hospitalo-Universitaire de Psychiatrie de Bicêtre, Mood Center Paris Saclay, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Saclay, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.
MOODS Team, INSERM 1018, CESP (Centre de Recherche en Epidémiologie et Santé des Populations), Université Paris-Saclay, Faculté de Médecine Paris-Saclay, Le Kremlin Bicêtre, France.
J Neurol Neurosurg Psychiatry. 2022 Aug 11. doi: 10.1136/jnnp-2021-328516.
Long COVID is a major public health issue. Whether long COVID is comorbid with psychiatric disorders remains unclear. Here, we investigate the association between long COVID, psychiatric symptoms and psychiatric disorders.
Cross-sectional.
Bicêtre Hospital, France, secondary care.
One hundred seventy-seven patients admitted in intensive care unit during acute phase and/or reporting long COVID complaints were assessed 4 months after hospitalisation for an acute COVID.
Eight long COVID complaints were investigated: fatigue, respiratory and cognitive complaints, muscle weakness, pain, headache, paraesthesia and anosmia. The number of complaints, the presence/absence of each COVID-19 complaint as well as lung CT scan abnormalities and objective cognitive impairment) were considered. Self-reported psychiatric symptoms were assessed with questionnaires. Experienced psychiatrists assessed Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition-based diagnoses of psychiatric disorders.
One hundred and fifteen (65%) patients had at least one long COVID complaint. The number of long COVID complaints was associated with psychiatric symptoms. The number of long COVID complaints was higher in patients with psychiatric disorders (mean (m) (SD)=2.47 (1.30), p<0.05), new-onset psychiatric disorders (m (SD)=2.41 (1.32), p<0.05) and significant suicide risk (m (SD)=2.67 (1.32), p<0.05) than in patients without any psychiatric disorder (m (SD)=1.43 (1.48)). Respiratory complaints were associated with a higher risk of psychiatric disorder and new-onset psychiatric disorder, and cognitive complaints were associated with a higher risk of psychiatric disorder.
Long COVID is associated with psychiatric disorders, new-onset psychiatric disorders and suicide risk. Psychiatric disorders and suicide risk should be systematically assessed in patients with long COVID.
新冠后综合征是一个重大的公共卫生问题。新冠后综合征是否与精神障碍共病仍不清楚。在此，我们调查新冠后综合征、精神症状和精神障碍之间的关联。
横断面研究。
法国比塞特尔医院，二级医疗保健机构。
177名在急性期入住重症监护病房和/或报告有新冠后综合征症状的患者，在因急性新冠住院4个月后接受评估。
调查了八项新冠后综合征症状：疲劳、呼吸和认知症状、肌肉无力、疼痛、头痛、感觉异常和嗅觉丧失。考虑了症状的数量、每项新冠后综合征症状的有无以及肺部CT扫描异常和客观认知障碍情况。通过问卷评估自我报告的精神症状。经验丰富的精神科医生根据《精神疾病诊断与统计手册》第五版对精神障碍进行诊断评估。
115名（65%）患者至少有一项新冠后综合征症状。新冠后综合征症状的数量与精神症状相关。有精神障碍的患者（平均（m）（标准差）=2.47（1.30），p<0.05）、新发精神障碍的患者（m（标准差）=2.41（1.32），p<0.05）和有显著自杀风险的患者（m（标准差）=2.67（1.32），p<0.05）的新冠后综合征症状数量高于无任何精神障碍的患者（m（标准差）=1.43（1.48））。呼吸症状与精神障碍和新发精神障碍的较高风险相关，认知症状与精神障碍的较高风险相关。
新冠后综合征与精神障碍、新发精神障碍和自杀风险相关。应对新冠后综合征患者系统地评估精神障碍和自杀风险。
