Poznan University of Medical Sciences, Poznan, Poland.
Chair and Department of Neonatology, Poznan University of Medical Sciences, Poznan, Poland.
Sci Rep. 2022 Aug 11;12(1):13679. doi: 10.1038/s41598-022-17820-w.
Sepsis in neonates carries a high morbidity and mortality rate and is among the most feared complications in the neonatal intensive care unit (NICU). Catheter-related bloodstream infections (CRBSI) are a common etiology of late-onset sepsis. The aim of this study was to compare risk factors and characteristics between patients according to the type of catheter that was utilized and according to birth weight classification. The study included 51 newborns with confirmed CRBSI, which were hospitalized in our level 3 NICU between January 2017 and December 2018. The study population was stratified according to the type of venous catheter utilized (peripherally inserted central catheter, central venous catheter (CVC), and peripheral venous catheter). Infants with low birth weight and those who required prolonged parenteral nutrition were most likely to develop CRBSI in our study group. The type of venous catheter was not associated with blood culture results. Also, infants with a birth weight of < 1500 g and > 1500 g did not differ in sepsis etiology. Further research is required to assess venous catheters relative risk of causing sepsis and if the outcome can be traced back specifically to catheter type or patient characteristics.
新生儿脓毒症的发病率和死亡率均较高,是新生儿重症监护病房(NICU)中最令人恐惧的并发症之一。导管相关性血流感染(CRBSI)是晚发性败血症的常见病因。本研究旨在比较根据所使用的导管类型以及根据出生体重分类的患者的危险因素和特征。该研究纳入了 2017 年 1 月至 2018 年 12 月在我们三级 NICU 住院的 51 例确诊为 CRBSI 的新生儿。研究人群根据静脉导管的类型(外周插入中心导管、中心静脉导管(CVC)和外周静脉导管)进行分层。在我们的研究组中,出生体重较低且需要长期肠外营养的婴儿最有可能发生 CRBSI。静脉导管的类型与血培养结果无关。此外,出生体重<1500g 和>1500g 的婴儿在败血症病因方面没有差异。需要进一步研究以评估静脉导管引起败血症的相对风险,以及结果是否可以具体追溯到导管类型或患者特征。