Imanishi Toshiyuki, Shimizu Masaki, Sumiya Wakako, Kanno Chika, Kanno Masayuki, Kanno Masami, Kawabata Ken
Division of Neonatology, Department of Maternal and Perinatal Center, Saitama Children's Medical Center, Saitama, Japan.
J Perinatol. 2022 Dec;42(12):1630-1636. doi: 10.1038/s41372-022-01486-3. Epub 2022 Aug 11.
We aimed to evaluate abnormal magnetic resonance imaging (MRI) findings in neonates with mild hypoxic-ischemic encephalopathy (HIE).
This was a single-center, retrospective study of mild HIE conducted from 2011 to 2020. Almost all neonates with mild HIE received management targeted to a temperature of 36 ± 0.5°C for 72 h and underwent MRI (135 of 145). We evaluated medical records and assessed amplitude-integrated electroencephalography (aEEG).
All participants survived until discharge. Abnormal MRI findings were present in 23/135 (17%) neonates. The normal versus abnormal MRI-finding groups had similar characteristics, except discontinuous aEEG patterns (p = 0.002) and inotropic drugs (p = 0.035). Regression analyses showed discontinuous aEEG patterns (odds ratio = 19.3, 95% confidence interval=1.88-197, p = 0.013) being associated with higher odds of abnormal MRI findings.
Our study suggests that a discontinuous aEEG pattern is associated with abnormal MRI findings and can be used to discuss the definition of mild HIE.
我们旨在评估轻度缺氧缺血性脑病（HIE）新生儿的磁共振成像（MRI）异常表现。
这是一项对2011年至2020年期间轻度HIE进行的单中心回顾性研究。几乎所有轻度HIE新生儿均接受了目标体温为36±0.5°C、持续72小时的治疗，并接受了MRI检查（145例中有135例）。我们评估了病历并进行了振幅整合脑电图（aEEG）评估。
所有参与者均存活至出院。135例新生儿中有23例（17%）存在MRI异常表现。MRI表现正常组与异常组具有相似的特征，但aEEG模式不连续（p = 0.002）和使用了血管活性药物（p = 0.035）的情况除外。回归分析显示，aEEG模式不连续（优势比=19.3，95%置信区间=1.88 - 197，p = 0.013）与MRI异常表现的较高几率相关。
我们的研究表明，aEEG模式不连续与MRI异常表现相关，可用于讨论轻度HIE的定义。
