新生儿轻度缺氧缺血性脑病治疗性低温治疗的神经发育结局。
Neurodevelopmental Outcomes in Neonates with Mild Hypoxic Ischemic Encephalopathy Treated with Therapeutic Hypothermia.
机构信息
Department of Pediatrics, Washington University in St Louis, St. Louis, Missouri.
Division of Newborn Medicine, Ann and Robert Laurie School of Medicine, Chicago, Illinois.
出版信息
Am J Perinatol. 2019 Nov;36(13):1337-1343. doi: 10.1055/s-0038-1676973. Epub 2019 Jan 4.
OBJECTIVE
To review developmental outcomes of neonates with mild hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH).
STUDY DESIGN
Neonates ≥35 weeks' gestation with mild HIE/TH (TH group, = 30) were matched with healthy term-born infants (control group, = 30) and reviewed for the presence and severity of magnetic resonance imaging (MRI)-detected neurological injury. Neurodevelopmental outcomes were assessed using the Bayley Scales of Infant Development (BSID).
RESULTS
MRI injury was present in 13/30 (43.3%) neonates (11 mild, 1 moderate, and 1 severe injuries) in the TH group. The mean (standard deviation [SD]) corrected age at BSID III was 29.3 (3.9) months in the controls compared with 14.7 (3.9) months in the TH group ( < 0.01). The mean (SD) cognitive, language, and motor composite scores in neonates in the TH group ( = 16, 53.3%) and control groups ( = 30, 100%) were 99.4 (17.1) versus 93.0 (12.3), ( = 0.15), 89.5 (15.5) versus 100.2 (18.4), ( = 0.054), and 93.1 (15.4) versus 100.8 (16.3) ( = 0.13), respectively.
CONCLUSION
Developmental outcomes of neonates with mild HIE/TH were similar to healthy, term-born neonates.
目的
回顾接受治疗性低温治疗的轻度缺氧缺血性脑病（HIE）新生儿的发育结局。
研究设计
对胎龄≥35 周的轻度 HIE/TH（TH 组，n=30）新生儿进行治疗性低温治疗，并与健康足月出生的婴儿（对照组，n=30）进行匹配，评估磁共振成像（MRI）检测到的神经损伤的存在和严重程度。使用贝利婴幼儿发展量表（BSID）评估神经发育结局。
结果
TH 组 30 例新生儿中，13 例（43.3%）存在 MRI 损伤（11 例轻度、1 例中度和 1 例重度损伤）。对照组 BSID III 校正年龄的平均值（标准差）为 29.3（3.9）个月，TH 组为 14.7（3.9）个月（<0.01）。TH 组（n=16，占 53.3%）和对照组（n=30，占 100%）新生儿的认知、语言和运动综合评分的平均值（SD）分别为 99.4（17.1）比 93.0（12.3）（=0.15）、89.5（15.5）比 100.2（18.4）（=0.054）和 93.1（15.4）比 100.8（16.3）（=0.13）。
结论
轻度 HIE/TH 新生儿的发育结局与健康足月出生的新生儿相似。
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