Neuroradiology Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Centre for Neurolinguistics and Psycholinguistics (CNPL), Università Vita-Salute San Raffaele, Via Olgettina, 58, 20132, Milan, Italy.
Sci Rep. 2022 Aug 11;12(1):13684. doi: 10.1038/s41598-022-17557-6.
Inhibitory control is the capacity to withhold or suppress a thought or action intentionally. The anterior Midcingulate Cortex (aMCC) participates in response inhibition, a proxy measure of inhibitory control. Recent research suggests that response inhibition is modulated by individual variability in the aMCC sulcal morphology. However, no study has investigated if this phenomenon is associated with neurofunctional differences during a task. In this study, 42 participants performed an Attention Network Task and a Numerical Stroop task in an MRI scanner. We investigated differences in brain activity and response inhibition efficiency between individuals with symmetric and asymmetric aMCC sulcal patterns. The results showed that aMCC morphological variability is partly associated with inhibitory control, and revealed greater activation in individuals with symmetric patterns during the Stroop task. Our findings provide novel insights into the functional correlates of the relationship between aMCC morphology and executive abilities.
抑制控制是指有意图地抑制或抑制思维或行动的能力。前扣带皮层（aMCC）参与反应抑制，这是抑制控制的一个替代测量指标。最近的研究表明，反应抑制受到 aMCC 脑回形态个体差异的调节。然而，尚无研究调查这种现象是否与任务期间的神经功能差异有关。在这项研究中，42 名参与者在 MRI 扫描仪中进行了注意力网络任务和数字斯特鲁普任务。我们研究了具有对称和不对称 aMCC 脑回模式的个体之间的大脑活动和反应抑制效率的差异。结果表明，aMCC 形态变异性部分与抑制控制有关，并且在斯特鲁普任务中具有对称模式的个体表现出更高的激活。我们的发现为 aMCC 形态与执行能力之间关系的功能相关性提供了新的见解。
