Nava H, Carlsson G, Petrelli N J, Herrera L, Mittelman A
Dis Colon Rectum. 1987 Jun;30(6):465-8. doi: 10.1007/BF02556498.
Forty-four asymptomatic patients with adenomatous colorectal polyps were followed by repeated colonoscopies and subsequent removal of new polyps. The median follow-up time was 34 months (range, 4 to 131 months). Twenty-six patients (59 percent) developed new adenomatous polyps. The recurrence rate was 69 percent in patients with multiple polyps compared with 54 percent in patients with a single polyp. The location of new polyps was in the same colonic segment in 81 percent of the patients, but not at the same site in the colon where a previous polyp had been removed. The histopathology and size of new polyps compared with the initial polyps showed a significant improvement in histopathology toward more benign polyps (P less than 0.02) and smaller polyps (P less than 0.001). In patients who initially had single adenomatous polyps, new polyp(s) were diagnosed after a mean time of 23 months compared with 13.5 months in patients with two or more adenomatous polyps initially. Patients with atypia in initial polyp(s) developed new polyp(s) after a mean time of 11 months compared with 23 months in patients without atypia. The mean time from a colon with no polyps to the diagnosis of a new adenomatous polyp less than 5 mm in size was 11.5 months, which was a statistically significant shorter time than the 19.4 months observed for the development of polyps 5 mm or larger.
44例无症状的大肠腺瘤性息肉患者接受了多次结肠镜检查，并随后切除新出现的息肉。中位随访时间为34个月（范围4至131个月）。26例患者（59%）出现了新的腺瘤性息肉。多发息肉患者的复发率为69%，而单发息肉患者的复发率为54%。81%的患者新息肉位于同一结肠段，但并非在先前已切除息肉的结肠部位。新息肉与初始息肉相比，其组织病理学和大小显示组织病理学向更良性的息肉显著改善（P<0.02）且息肉更小（P<0.001）。最初有单个腺瘤性息肉的患者，新息肉诊断的平均时间为23个月，而最初有两个或更多腺瘤性息肉的患者为13.5个月。初始息肉有异型增生的患者出现新息肉的平均时间为11个月，而无异型增生的患者为23个月。从无息肉的结肠到诊断出大小小于5mm的新腺瘤性息肉的平均时间为11.5个月，这在统计学上显著短于观察到的5mm或更大息肉出现的19.4个月。
