Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, 410008, Hunan, China.
Clin Transl Oncol. 2022 Dec;24(12):2441-2452. doi: 10.1007/s12094-022-02915-7. Epub 2022 Aug 11.
Complete resection combined with postoperative radiotherapy is ideal for skull base chordomas. The recent literature suggests that the degree of surgical resection is the most important prognostic factor.
We retrospectively analyzed the clinical data of 16 patients with initial chordoma treated at our center between August 2015 and December 2021 and conducted a retrospective study on the prognosis of surgical treatment of skull base chordoma between 2013 and 2022.
According to the Kaplan-Meier method, there was a significant difference in PFS between patients aged > 50 years and < 50 years, and no significant difference was observed in PFS for tumor involvement of the internal carotid artery, dura, or superior or inferior clivus. However, there was still a correlation with prognosis. As observed in the included literature, the 5-year overall survival rate was significantly higher in patients undergoing total skull base chordoma resection than in those undergoing subtotal resection (STR), which in turn was significantly higher than in those undergoing partial resection (PR). Patients undergoing subtotal resection had significantly better 5-year PFS rates than those undergoing PR.
Our study shows that gross total resection and STR have better survival in patients with skull base chordomas compared to PR.
对于颅底脊索瘤，完全切除联合术后放疗是理想的治疗方法。最近的文献表明，手术切除程度是最重要的预后因素。
我们回顾性分析了 2015 年 8 月至 2021 年 12 月在我院治疗的 16 例初诊脊索瘤患者的临床资料，并对 2013 年至 2022 年颅底脊索瘤手术治疗的预后进行了回顾性研究。
根据 Kaplan-Meier 法，年龄>50 岁和<50 岁的患者在 PFS 方面存在显著差异，而颈内动脉、硬脑膜或上、下斜坡受累对 PFS 无显著影响。然而，这仍然与预后相关。在纳入的文献中观察到，行颅底脊索瘤全切除的患者 5 年总生存率明显高于行次全切除（STR）的患者，STR 又明显高于行部分切除（PR）的患者。行次全切除的患者 5 年 PFS 率明显高于行 PR 的患者。
我们的研究表明，与 PR 相比，颅底脊索瘤患者行全切除和 STR 有更好的生存获益。
