Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
The Second Hospital of Dalian Medical University, Dalian Medical University, Dalian 116000, China.
J Zhejiang Univ Sci B. 2022 Aug 15;23(8):655-665. doi: 10.1631/jzus.B2200154.
The global outbreak of the coronavirus disease 2019 (COVID-19) led to the suspension of most treatments with assisted reproductive technique (ART). However, with the recent successful control of the pandemic in China, there is an urgent public need to resume full reproductive care. To determine whether the COVID-19 pandemic had any adverse effects on female fertility and the pregnancy outcomes of women undergoing ART, a systematic review and meta-analysis was conducted using the electronic Chinese and English databases. Dichotomous outcomes were summarized as prevalence, and odds ratios (ORs) and continuous outcomes as standardized mean difference (SMD) with 95% confidence interval (CI). The risk of bias and subgroup analyses were assessed using Stata/SE 15.1 and R 4.1.2. The results showed that compared with women treated by ART in the pre-COVID-19 time frame, women undergoing ART after the COVID-19 pandemic exhibited no significant difference in the clinical pregnancy rate (OR 1.07, 95% CI 0.97 to 1.19; =0.0%), miscarriage rate (OR 0.95, 95% CI 0.79 to 1.14; =38.4%), embryo cryopreservation rate (OR 2.90, 95% CI 0.17 to 48.13; =85.4%), and oocyte cryopreservation rate (OR 0.30, 95% CI 0.03 to 3.65; =81.6%). This review provided additional evidence for gynecologists to guide the management of women undergoing ART treatment during the COVID-19 pandemic timeframe.
新型冠状病毒肺炎（COVID-19）在全球的爆发导致大多数辅助生殖技术（ART）治疗暂停。然而，随着中国最近成功控制疫情，公众迫切需要恢复全面的生殖护理。为了确定 COVID-19 大流行是否对女性生育能力和接受 ART 的女性的妊娠结局产生任何不良影响，使用电子中文和英文数据库进行了系统评价和荟萃分析。二项分类结局以患病率总结，比值比（OR）和连续结局以标准化均数差（SMD）和 95%置信区间（CI）表示。使用 Stata/SE 15.1 和 R 4.1.2 评估偏倚风险和亚组分析。结果表明，与 COVID-19 前接受 ART 治疗的女性相比，COVID-19 大流行后接受 ART 的女性的临床妊娠率（OR 1.07，95%CI 0.97 至 1.19；=0.0%）、流产率（OR 0.95，95%CI 0.79 至 1.14；=38.4%）、胚胎冷冻保存率（OR 2.90，95%CI 0.17 至 48.13；=85.4%）和卵母细胞冷冻保存率（OR 0.30，95%CI 0.03 至 3.65；=81.6%）均无显著差异。本综述为妇科医生在 COVID-19 大流行期间指导接受 ART 治疗的女性管理提供了额外的证据。
