Department of Liver Disease Center, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, China.
Department of Organ Transplantation Center, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, China.
BMC Surg. 2022 Aug 11;22(1):311. doi: 10.1186/s12893-022-01761-2.
Liver transplantation is one of the most effective treatments for end-stage liver disease. Split liver transplantation (SLT) can effectively improve the utilization efficiency of grafts. However, split liver transplantation still faces shortcomings and is not widely used in surgery. How to improve the effective transplantation volume of split liver transplantation and promote the postoperative recovery of patients has important clinical significance.
In our study, the donor's liver was split into the extended right graft and left lateral sector, and the IV segment occur ischemia. To guarantee the functional graft size, and avoid complications, we reconstructed the IV segment portal vein and left portal vein. And we analyzed the operation time, intraoperative bleeding, liver function, and postoperative complications.
In our research, 14 patients underwent IV segment portal vein reconstruction, and 8 patients did not undergo vascular reconstruction. We found that the ischemic area of the IV segment decreased significantly after IV segment portal vein reconstruction. We found that there was no significant difference in operation time and postoperative complications between the patients of the groups. There were significant differences in ALT on the 1st day and albumin on the 6th day after the operation.
It indicates that IV segment reconstruction in SLT surgery can alleviate the graft ischemic and promote the recovery of liver function after the operation. And, IV segment reconstruction as a novel operating procedure may be widely used in SLT.
肝移植是治疗终末期肝病最有效的方法之一。劈离式肝移植(SLT)可以有效地提高供肝的利用率。然而,劈离式肝移植仍存在一些不足,在手术中尚未广泛应用。如何提高劈离式肝移植的有效移植体积,促进患者术后恢复,具有重要的临床意义。
本研究中,供肝被劈分为扩展右半肝和左外叶,第四段发生缺血。为保证功能移植物的大小,避免并发症,我们对第四段门静脉和左门静脉进行了重建。并分析了手术时间、术中出血量、肝功能和术后并发症。
在我们的研究中,有 14 例患者进行了第四段门静脉重建,8 例患者未进行血管重建。我们发现第四段门静脉重建后第四段的缺血面积明显减少。我们发现两组患者在手术时间和术后并发症方面没有显著差异。术后第 1 天和第 6 天的 ALT 和白蛋白有显著差异。
SLT 术中第四段重建可以减轻供肝缺血,促进术后肝功能恢复。而且,第四段重建作为一种新的手术操作,可能会在 SLT 中广泛应用。