Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, 430030, Hubei, China.
J Nanobiotechnology. 2022 Aug 11;20(1):374. doi: 10.1186/s12951-022-01566-8.
Ovarian aging is characterized by a progressive decline in ovarian function. With the increase in life expectancy worldwide, ovarian aging has gradually become a key health problem among women. Over the years, various strategies have been developed to preserve fertility in women, while there are currently no clinical treatments to delay ovarian aging. Recently, advances in biomaterials and technologies, such as three-dimensional (3D) printing and microfluidics for the encapsulation of follicles and nanoparticles as delivery systems for drugs, have shown potential to be translational strategies for ovarian aging. This review introduces the research progress on the mechanisms underlying ovarian aging, and summarizes the current state of biomaterials in the evaluation and treatment of ovarian aging, including safety, potential applications, future directions and difficulties in translation.
卵巢衰老的特征是卵巢功能逐渐下降。随着全球预期寿命的延长，卵巢衰老逐渐成为女性的一个主要健康问题。多年来，已经开发出各种策略来保存女性的生育能力，而目前还没有临床治疗方法来延缓卵巢衰老。最近，生物材料和技术的进步，如三维（3D）打印和微流控技术用于包裹卵泡，以及纳米颗粒作为药物传递系统，显示出作为卵巢衰老转化策略的潜力。本文介绍了卵巢衰老机制的研究进展，并总结了生物材料在评估和治疗卵巢衰老方面的现状，包括安全性、潜在应用、未来方向和转化中的困难。
