Oyeyinka Barnabas Oluwatomide, Afolayan Anthony Jide
Medicinal Plants and Economic Development (MPED) Research Centre, Botany Department, University of Fort Hare, Alice 5700, South Africa.
Foods. 2022 Jul 29;11(15):2263. doi: 10.3390/foods11152263.
Active principles in plant-based foods, especially staple fruits, such as bananas and plantains, possess inter-related anti-inflammatory, anti-apoptotic, antioxidative, and neuromodulatory activities. Neurodegenerative diseases affect the functionality of the central and peripheral nervous system, with attendant cognitive deficits being hallmarks of these conditions. The dietary constitution of a wide range of bioactive compounds identified in this review further iterates the significance of the banana and plantain in compromising, halting, or preventing the pathological mechanisms of neurological disorders. The neuroprotective mechanisms of these biomolecules have been identified by using protein expression regulation and specific gene/pathway targeting, such as the nuclear and tumor necrosis factors, extracellular signal-regulated and mitogen-activated protein kinases, activator protein-1, and the glial fibrillary acidic protein. This review establishes the potential double-edged neuro-pharmacological fingerprints of banana and plantain fruits in their traditionally consumed pulp and less utilized peel component for human nutrition.
植物性食物中的活性成分，尤其是主食类水果，如香蕉和大蕉，具有相互关联的抗炎、抗凋亡、抗氧化和神经调节活性。神经退行性疾病会影响中枢和周围神经系统的功能，伴随的认知缺陷是这些病症的标志。本综述中确定的多种生物活性化合物的饮食构成进一步强调了香蕉和大蕉在损害、阻止或预防神经疾病病理机制方面的重要性。通过蛋白质表达调控和特定基因/途径靶向，如核因子和肿瘤坏死因子、细胞外信号调节激酶和丝裂原活化蛋白激酶、活化蛋白-1以及胶质纤维酸性蛋白，已确定了这些生物分子的神经保护机制。本综述确立了香蕉和大蕉果实中传统食用果肉及较少利用的果皮成分在人类营养方面潜在的双刃剑式神经药理学特性。
