Ferrante Margherita, Distefano Giulia, Distefano Carlo, Copat Chiara, Grasso Alfina, Oliveri Conti Gea, Cristaldi Antonio, Fiore Maria
Department of Medical, Surgical and Advanced Technologies "G.F. Ingrassia", University of Catania, 95123 Catania, Italy.
Cancers (Basel). 2022 Jul 27;14(15):3657. doi: 10.3390/cancers14153657.
Several epidemiological studies have provided evidence of the usefulness of physical activity for cancer prevention, increased survival and quality of life (QoL), but no comprehensive review is available on the effects on thyroid cancer. The present systematic review provides an overview of the effects of physical activity on fatigue, QoL and health-related quality of life (HRQoL) in patients with thyroid cancer diagnosis both during and after treatment, with a focus on sex.
A literature search was conducted in the PubMed and Scopus databases. We included studies investigating the impact of physical activity during and after thyroid cancer treatment, including fatigue, QoL and/or HRQoL among the outcomes. Review articles, conference papers, short communications and articles written in a language other than English articles were excluded. Study selection followed the preferred reporting items for systematic reviews and meta-analyses guidelines (PRISMA). Two reviewers independently selected the studies and assessed their eligibility. The same two reviewers independently screened studies, extracted data and assessed the risk of bias. Outcomes of interest were fatigue, QoL and HRQoL. The Newcastle-Ottawa Scale was used to assess the quality of the selected studies. We compared the outcomes between groups of patients with subclinical hyperthyroidism undergoing a physical activity program and a sedentary group, evaluating the possible presence of sex differences.
We found five studies eligible for inclusion in our review; only two were prospective studies including an exercise training program. One study was a quasi-experimental study with a non-equivalent control group. Three out of five studies comprised low-quality evidence with a high risk of bias.
The level of confidence in the available evidence is very low. A close association between physical activity and fatigue, QoL and HRQoL in patients with thyroid cancer diagnosis with a focus on sex can neither be supported nor refuted. Future studies are needed to understand which training programs are optimal, both in terms of beneficial effects and to avoid potential adverse responses, in addition to focusing on gender differences. The protocol of this systematic review was registered with PROSPERO: CRD42022322519.
多项流行病学研究已提供证据表明体育活动对癌症预防、提高生存率和生活质量（QoL）有益，但尚无关于其对甲状腺癌影响的全面综述。本系统综述概述了体育活动对甲状腺癌患者治疗期间和治疗后疲劳、生活质量和健康相关生活质量（HRQoL）的影响，并重点关注性别差异。
在PubMed和Scopus数据库中进行文献检索。我们纳入了调查甲状腺癌治疗期间和治疗后体育活动影响的研究，包括疲劳、生活质量和/或健康相关生活质量等结果。综述文章、会议论文、简短通讯以及非英文撰写的文章均被排除。研究选择遵循系统评价和Meta分析的首选报告项目（PRISMA）指南。两名评审员独立选择研究并评估其合格性。同样由这两名评审员独立筛选研究、提取数据并评估偏倚风险。感兴趣的结果为疲劳、生活质量和健康相关生活质量。使用纽卡斯尔-渥太华量表评估所选研究的质量。我们比较了接受体育活动计划的亚临床甲状腺功能亢进患者组和久坐不动组之间的结果，评估了可能存在的性别差异。
我们发现五项研究符合纳入本综述的条件；只有两项是前瞻性研究，包括运动训练计划。一项研究是具有非等效对照组的准实验研究。五项研究中有三项证据质量低，存在高偏倚风险。
现有证据的可信度非常低。无法支持或反驳体育活动与甲状腺癌患者的疲劳、生活质量和健康相关生活质量之间的密切关联（重点关注性别差异）。除了关注性别差异外，未来还需要开展研究，以了解哪些训练计划在有益效果方面是最佳的，同时避免潜在的不良反应。本系统综述的方案已在PROSPERO注册：CRD42022322519。
Zotero 插件