Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy.
CREAGEN-Environmental, Genetic and Nutritional Epidemiology Research Center, Section of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Int J Environ Res Public Health. 2022 Jul 30;19(15):9362. doi: 10.3390/ijerph19159362.
Aluminum is an element found in nature and in cosmetic products. It can interfere with the metabolism of other cations, thus inducing gastrointestinal disorder. In cosmetics, aluminum is used in antiperspirants, lipsticks, and toothpastes. The aim of this work is to investigate aluminum bioavailability after accidental oral ingestion derived from the use of a toothpaste containing a greater amount of aluminum hydroxide than advised by the Scientific Committee on Consumer Safety (SCCS). To simulate in vitro toothpaste accidental ingestion, the INFOGEST model was employed, and the amount of aluminum was measured through the ICP-AES analysis. Tissue barrier integrity was analyzed by measuring transepithelial electric resistance, and the tissue architecture was checked through light microscopy. The margin of safety was also calculated. Overall, our results indicate that the acute exposure to aluminum accidentally ingested from toothpastes is safe for the final user, even in amounts higher than SCCS indications.
铝是一种在自然界和化妆品中都存在的元素。它可以干扰其他阳离子的新陈代谢，从而引起胃肠道紊乱。在化妆品中，铝被用于止汗剂、口红和牙膏中。这项工作的目的是研究由于使用含有比消费者安全科学委员会（SCCS）建议量更多的氢氧化铝的牙膏而导致意外口服摄入后的铝的生物利用度。为了模拟体外牙膏意外摄入，采用 INFOGEST 模型，并通过 ICP-AES 分析测量铝的含量。通过测量跨上皮电阻来分析组织屏障完整性，并通过光学显微镜检查组织结构。还计算了安全边际。总的来说，我们的结果表明，即使摄入的牙膏中的铝量超过了 SCCS 的指示量，对于最终使用者来说，意外摄入的急性铝暴露也是安全的。
