Maci R, Arias E
Ecotoxicol Environ Saf. 1987 Apr;13(2):169-73. doi: 10.1016/0147-6513(87)90004-2.
The teratogenicity of a commercial formulation of the fungicide maneb (Maneb 80, containing 80% manganese ethylenebisdithiocarbamate and 20% inert ingredients) in chick embryos was evaluated. Unincubated eggs (157-207 per treatment group) were immersed in 0.5, 1.5, 4.5, or 13.5 g/liter maneb aqueous solutions for 30 sec. Two control groups were used: one group of 200 eggs was immersed in tap water and a second group of 205 eggs was immersed in a solution of the inert ingredients (sodium lignin sulfonate and n-butylnaphthalene sulfonate) at the concentration present in the 13.5 g/liter maneb solution. Eggs were then incubated for 19 days. A single treatment with maneb was teratogenic at all concentrations tested, producing mainly unilateral lower limb deformities. No adverse effects on development were noticed after exposure to the inert ingredients.
对杀菌剂代森锰（代森锰80，含80%的乙撑双二硫代氨基甲酸锰和20%的惰性成分）的一种商业制剂对鸡胚的致畸性进行了评估。将未孵化的鸡蛋（每个处理组157 - 207枚）浸入0.5、1.5、4.5或13.5克/升的代森锰水溶液中30秒。使用了两个对照组：一组200枚鸡蛋浸入自来水中，另一组205枚鸡蛋浸入13.5克/升代森锰溶液中所含浓度的惰性成分（木质素磺酸钠和萘磺酸钠）溶液中。然后将鸡蛋孵化19天。在所有测试浓度下，单次使用代森锰均具有致畸性，主要产生单侧下肢畸形。暴露于惰性成分后未发现对发育有不良影响。
