López-Píriz Roberto, Goyos-Ball Lidia, Cabal Belén, Martínez Susana, Moya José S, Bartolomé José F, Torrecillas Ramón
Instituto de Cirugía Oral Avanzada-ICOA, Calle de Fray Luis de León, 14, 28012 Madrid, Spain.
Nanoker Research, Pol. Ind. Olloniego, Parcela 22A, Nave 5, 33660 Oviedo, Spain.
Materials (Basel). 2022 Aug 6;15(15):5422. doi: 10.3390/ma15155422.
The choice of suitable materials and new designs in oral implantology and the subsequent enhancement of the characteristics of the dental implant developed is an important research topic with wide scope. The present work aims to develop a new multifunctional zirconia-ceria/alumina (Ce-TZP/AlO) composite with an antimicrobial glass-based coating to be used in multi-unit abutments compatible with commercially available Ti implants for peri-implantitis prevention. An airbrush spraying technique was effectively applied to coat the sintered ceramic composite starting from a glass powder suspension. This deposition technique was appropriate for obtaining continuous antimicrobial glass-based coatings with homogenous thickness (~35 µm) on ceramic dental implant components. The dental implant systems with the antimicrobial glassy coating were subjected to a mechanical integrity test following ISO 14801 to determine their long-term stability. The tested implant-coating structure seems to be stable under in vitro conditions with ultimate applied forces exceeding the maximum physiological occlusal loading force. This paper also presents a pilot clinical case report that shows peri-implant tissue around the mechanically stable glass coating with no signs of inflammation 1 year after implant insertion. This result is a preliminary probe of the durability and biological tolerance of the glassy material by the gingiva, as well as the antimicrobial effect on the peri-implant microbiota displayed by the coating.
口腔种植学中合适材料和新设计的选择以及随后对所开发牙种植体特性的提升是一个具有广泛范围的重要研究课题。本研究旨在开发一种新型多功能氧化锆 - 二氧化铈/氧化铝（Ce - TZP/AlO）复合材料，并带有抗菌玻璃基涂层，用于与市售钛种植体兼容的多单位基台，以预防种植体周围炎。从玻璃粉末悬浮液开始，通过喷枪喷涂技术有效地应用于烧结陶瓷复合材料的涂层。这种沉积技术适合在牙科陶瓷种植体部件上获得具有均匀厚度（约35μm）的连续抗菌玻璃基涂层。对带有抗菌玻璃涂层的牙种植体系统按照ISO 14801进行机械完整性测试，以确定其长期稳定性。在体外条件下，测试的种植体 - 涂层结构在最终施加力超过最大生理咬合加载力时似乎是稳定的。本文还展示了一个初步的临床病例报告，该报告显示在种植体植入1年后，机械稳定的玻璃涂层周围的种植体周围组织没有炎症迹象。这一结果是对玻璃材料在牙龈中的耐久性和生物耐受性以及涂层对种植体周围微生物群的抗菌作用的初步探索。
