Kv10.1 通道：癌症治疗的有前景靶点

Cátedras CONACYT-Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Circuito Exterior s/n, C.U., Ciudad de México 04510, Mexico.

Laboratorio Nacional de Canalopatías, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Circuito Exterior s/n, C.U., Ciudad de México 04510, Mexico.

Int J Mol Sci. 2022 Jul 30;23(15):8458. doi: 10.3390/ijms23158458.

Carcinogenesis is a multistage process involving the dysregulation of multiple genes, proteins, and pathways that make any normal cell acquire a cancer cell phenotype. Therefore, it is no surprise that numerous ion channels could be involved in this process. Since their discovery and subsequent cloning, ion channels have been established as therapeutic targets in excitable cell pathologies (e.g., cardiac arrhythmias or epilepsy); however, their involvement in non-excitable cell pathologies is relatively recent. Among all ion channels, the voltage-gated potassium channels Kv10.1 have been established as a promising target in cancer treatment due to their high expression in tumoral tissues compared to low levels in healthy tissues.

癌症发生是一个多阶段的过程，涉及多个基因、蛋白质和途径的失调，使任何正常细胞获得癌细胞表型。因此，许多离子通道可能参与这个过程也就不足为奇了。自从发现和随后克隆以来，离子通道已被确立为可兴奋细胞病变（例如，心律失常或癫痫）的治疗靶点；然而，它们在非可兴奋细胞病变中的参与相对较新。在所有离子通道中，电压门控钾通道 Kv10.1 由于其在肿瘤组织中的高表达与健康组织中的低水平相比，已被确立为癌症治疗的有希望的靶点。