School of Pharmacy, College of Health Sciences, University of Wyoming, Laramie, WY 82071, USA.
Int J Mol Sci. 2022 Aug 3;23(15):8608. doi: 10.3390/ijms23158608.
Epilepsy is an international public health concern that greatly affects patients' health and lifestyle. About 30% of patients do not respond to available therapies, making new research models important for further drug discovery. Aquatic vertebrates present a promising avenue for improved seizure drug screening and discovery. Zebrafish () and African clawed frogs and are increasing in popularity for seizure research due to their cost-effective housing and rearing, similar genome to humans, ease of genetic manipulation, and simplicity of drug dosing. These organisms have demonstrated utility in a variety of seizure-induction models including chemical and genetic methods. Past studies with these methods have produced promising data and generated questions for further applications of these models to promote discovery of drug-resistant seizure pathology and lead to effective treatments for these patients.
癫痫是一个国际公共卫生关注点，极大地影响了患者的健康和生活方式。大约 30%的患者对现有疗法没有反应，因此新的研究模型对于进一步的药物发现非常重要。水生脊椎动物为改善癫痫药物筛选和发现提供了一个很有前景的途径。斑马鱼和非洲爪蟾由于其具有成本效益的住房和饲养、与人类相似的基因组、易于遗传操作以及药物剂量简单，越来越受到癫痫研究的欢迎。这些生物在多种癫痫诱导模型中具有实用性，包括化学和遗传方法。过去使用这些方法的研究产生了有前景的数据，并为进一步应用这些模型以促进发现耐药性癫痫病理和为这些患者提供有效治疗提出了问题。
