Bălă Gabriel-Petrică, Timar Bogdan, Gorun Florin, Motisan Radu, Pescaru Camelia, Tudorache Emanuela, Marc Monica, Manolescu Diana, Citu Cosmin, Oancea Cristian
Center for Research and Innovation in Precision Medicine of Respiratory Diseases, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Department of Internal Medicine II, Division of Diabetes, Nutrition and Metabolic Diseases, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
J Clin Med. 2022 Jul 27;11(15):4352. doi: 10.3390/jcm11154352.
Patients with respiratory pathologies are the risk group most affected by air pollution, being directly exposed, especially those diagnosed with chronic obstructive pulmonary disease (COPD). In this observational study, which included 79 patients, we evaluated whether COPD patients with the frequent exacerbating phenotype or the infrequent exacerbating phenotype live in residences with higher values of air pollution. An air quality monitoring station was installed in each patient's house for at least 24 h and PM 1.0, PM 2.5, and PM 10 were measured. Average PM 1.0, PM 2.5, and PM 10 values were lower in the group of infrequently exacerbating patients compared to the frequently exacerbating ones. For every 1 µg/m increase in the average values of PM 1.0, PM 2.5, and PM 10, there is an increase of 1.7%, 1.8% and 1%, respectively, in the risk of developing exacerbations. More importantly, an average value of PM 1.0, PM 2.5, and PM 10 above 32.21 µg/m, 82.32 µg/m and 42.89 µg/m increases the probability of developing an exacerbation by 3.83, 10.14, and 4.12 times, respectively. Our analysis showed that COPD patients with a frequently exacerbating phenotype live in residences with high levels of air pollution compared to infrequently exacerbating ones.
患有呼吸道疾病的患者是受空气污染影响最严重的风险群体，尤其是那些被诊断为慢性阻塞性肺疾病（COPD）的患者，他们会直接暴露于空气污染中。在这项纳入了79名患者的观察性研究中，我们评估了具有频繁加重型或不频繁加重型表型的慢性阻塞性肺疾病患者是否居住在空气污染值较高的住所。在每位患者家中安装一个空气质量监测站至少24小时，并测量PM 1.0、PM 2.5和PM 10。与频繁加重型患者组相比，不频繁加重型患者组的PM 1.0、PM 2.5和PM 10平均数值更低。PM 1.0、PM 2.5和PM 10的平均值每增加1 µg/m，病情加重的风险分别增加1.7%、1.8%和1%。更重要的是，PM 1.0、PM 2.5和PM 10的平均值分别高于32.21 µg/m、82.32 µg/m和42.89 µg/m时，病情加重的概率分别增加3.83倍、10.14倍和4.12倍。我们的分析表明，与不频繁加重型患者相比，具有频繁加重型表型的慢性阻塞性肺疾病患者居住在空气污染水平较高的住所。
