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Lancet. 2022 Jun 4;399(10341):2113-2128. doi: 10.1016/S0140-6736(22)00581-5. Epub 2022 May 26.
2
Etrolizumab versus infliximab for the treatment of moderately to severely active ulcerative colitis (GARDENIA): a randomised, double-blind, double-dummy, phase 3 study.依特利珠单抗与英夫利昔单抗治疗中重度活动性溃疡性结肠炎（GARDENIA）的随机、双盲、双模拟、3 期研究。
Lancet Gastroenterol Hepatol. 2022 Feb;7(2):118-127. doi: 10.1016/S2468-1253(21)00294-6. Epub 2021 Nov 17.
3
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N Engl J Med. 2021 Sep 30;385(14):1280-1291. doi: 10.1056/NEJMoa2033617.
4
PTG-100, an Oral α4β7 Antagonist Peptide: Preclinical Development and Phase 1 and 2a Studies in Ulcerative Colitis.PTG-100，一种口服 α4β7 拮抗剂肽：在溃疡性结肠炎中的临床前开发和 1 期和 2a 期研究。
Gastroenterology. 2021 Dec;161(6):1853-1864.e10. doi: 10.1053/j.gastro.2021.08.045. Epub 2021 Aug 30.
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7
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炎症性肠病（IBD）的新型疗法与方法

Novel Therapies and Approaches to Inflammatory Bowel Disease (IBD).

作者信息

Furfaro Federica, Ragaini Elisa, Peyrin-Biroulet Laurent, Danese Silvio

机构信息

Department of Gastroenterology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, 20132 Milan, Italy.

Department of Biomedical Sciences, Humanitas University, 20090 Milan, Italy.

出版信息

J Clin Med. 2022 Jul 28;11(15):4374. doi: 10.3390/jcm11154374.

DOI:10.3390/jcm11154374
PMID:35955992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9369414/
Abstract

Inflammatory bowel diseases (IBDs), divided into two predominant groups, Crohn's disease (CD) and ulcerative colitis (UC), are chronic relapsing inflammatory diseases of the gastrointestinal tract, resulting from an aberrant immune response to microbes in the gut, in genetically susceptible patients [...].

摘要

炎症性肠病（IBDs）分为两个主要类型，即克罗恩病（CD）和溃疡性结肠炎（UC），是胃肠道的慢性复发性炎症性疾病，由基因易感患者肠道内对微生物的异常免疫反应引起[...]。