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Pseudonajatoxin b: unusual amino acid sequence of a lethal neurotoxin from the venom of the Australian common brown snake, Pseudonaja textilis.

作者信息

Tyler M I, Spence I, Barnett D, Howden M E

出版信息

Eur J Biochem. 1987 Jul 1;166(1):139-43. doi: 10.1111/j.1432-1033.1987.tb13493.x.

DOI:10.1111/j.1432-1033.1987.tb13493.x
PMID:3595609
Abstract

The complete amino acid sequence of pseudonajatoxin b, a basic neurotoxin from the venom of the Australian common brown snake, Pseudonaja textilis, was determined by automated Edman analysis of the reduced carboxymethylated polypeptide and of peptides derived by digestion of it with Staphylococcus aureus V8 proteinase. Pseudonajatoxin b consists of a single polypeptide chain of 71 amino acids with Mr 7762. The amino acid sequence showed considerable homology with postsynaptic long neurotoxins, but there were striking differences. Pseudonajatoxin b displayed relatively high lethality, LD50 15 micrograms/kg in mice.

摘要

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