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一名2岁儿童的急性硒中毒

Acute selenium poisoning of a 2-year-old child.

作者信息

Lombeck I, Menzel H, Frosch D

出版信息

Eur J Pediatr. 1987 May;146(3):308-12. doi: 10.1007/BF00716483.

DOI:10.1007/BF00716483
PMID:3595654
Abstract

After ingestion of an unknown amount of a gun blueing compound containing selenious acid (11 ml from the bottle fluid were missing, equivalent to 2.9 g Se) a 2-year-old girl suffered from continuous hyper-salivation, vomiting, diarrhoea, restlessness and muscle spasm. Blood pressure and pulse rate were increased. Symptomatic treatment was performed by parenteral fluid administration. The plasma Se concentration was increased to 20 times normal 5 h after ingestion. Erythrocyte Se exceeded plasma Se, 24 h after intoxication. Urinary Se excretion decreased parallel to the plasma Se concentration. Ten weeks later, the Se content of hair had risen to 10 times normal. The plasma glutathione peroxidase activity showed only a slight increase during the first 36 h, erythrocyte glutathione peroxidase, catalase and superoxide dismutase activities were not significantly altered. The child fully recovered.

摘要

一名2岁女童摄入了未知量的含亚硒酸的枪支发蓝化合物(瓶中液体有11毫升缺失,相当于2.9克硒)后,出现持续流涎过多、呕吐、腹泻、烦躁不安和肌肉痉挛。血压和脉搏率升高。通过肠胃外补液进行了对症治疗。摄入后5小时,血浆硒浓度增至正常水平的20倍。中毒24小时后,红细胞硒含量超过血浆硒。尿硒排泄量与血浆硒浓度平行下降。十周后,头发中的硒含量升至正常水平的10倍。血浆谷胱甘肽过氧化物酶活性在最初36小时仅略有增加,红细胞谷胱甘肽过氧化物酶、过氧化氢酶和超氧化物歧化酶活性未发生显著改变。该儿童完全康复。

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1
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本文引用的文献

1
Toxicity of dimethyl selenide in the rat and mouse.二甲基硒对大鼠和小鼠的毒性
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Effect of dietary methionine on the biopotency of selenite and selenomethionine in the rat.膳食蛋氨酸对大鼠体内亚硒酸盐和硒代蛋氨酸生物效价的影响。
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Chromosomal effects of sodium selenite in vivo. I. Aberrations and sister chromatid exchanges in human lymphocytes.亚硒酸钠在体内的染色体效应。I. 人淋巴细胞中的畸变和姐妹染色单体交换
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Toxicology of selenium: a review.硒的毒理学:综述
Clin Toxicol. 1980 Sep;17(2):171-230. doi: 10.3109/15563658008985076.
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Endemic selenium intoxication of humans in China.中国人体的地方性硒中毒
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Catalase in vitro.体外过氧化氢酶
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Assays of glutathione peroxidase.谷胱甘肽过氧化物酶的测定
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Dietary selenium levels needed to maintain balance in North American adults consuming self-selected diets.北美成年人在食用自选饮食时维持平衡所需的膳食硒水平。
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Utilizing selenious acid to reverse selenium deficiency in total parenteral nutrition patients.
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