胃癌中的 HIF：调控与治疗靶点

Shenzhen Key Laboratory of Gastrointestinal Cancer Translational Research, Department of Oncology, Peking University Shenzhen Hospital, Cancer Institute of Shenzhen-PKU-HKUST Medical Center, Shenzhen 518036, China.

Department of Pathology, Peking University Shenzhen Hospital, Shenzhen 518036, China.

Molecules. 2022 Jul 31;27(15):4893. doi: 10.3390/molecules27154893.

HIF means hypoxia-inducible factor gene family, and it could regulate various biological processes, including tumor development. In 2021, the FDA approved the new drug Welireg for targeting HIF-2a, and it is mainly used to treat von Hippel-Lindau syndrome, which demonstrated its good prospects in tumor therapy. As the fourth deadliest cancer worldwide, gastric cancer endangers the health of people all across the world. Currently, there are various treatment methods for patients with gastric cancer, but the five-year survival rate of patients with advanced gastric cancer is still not high. Therefore, here we reviewed the regulatory role and target role of HIF in gastric cancer, and provided some references for the treatment of gastric cancer.

HIF 是缺氧诱导因子基因家族的英文缩写，它可以调节多种生物过程，包括肿瘤的发生发展。2021 年，FDA 批准了针对 HIF-2a 的新药 Welireg，主要用于治疗 von Hippel-Lindau 综合征，这表明其在肿瘤治疗方面具有广阔的前景。胃癌是全球第四大致死癌症，危害着全世界人民的健康。目前，胃癌患者有多种治疗方法，但晚期胃癌患者的五年生存率仍然不高。因此，我们在这里综述了 HIF 在胃癌中的调控作用和靶点作用，为胃癌的治疗提供了一些参考。