Brogden R N, Heel R C, Pakes G E, Speight T M, Avery G S
Drugs. 1980 Jul;20(1):24-48. doi: 10.2165/00003495-198020010-00002.
Diclofenac sodium, a phenylacetic acid derivative, is a non-steroidal, anti-inflammatory, analgesic agent advocated for use in rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and allied conditions, and in the treatment of pain resulting from minor surgery, trauma and dysmenorrhoea. Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis. Available data suggest that in patients with osteoarthritis diclofenac sodium is comparable in efficacy and tolerability with naproxen, ibuprofen, sulindac and diflunisal. As oral diclofenac is generally given in 3 divided daily doses it may be at a disadvantage relative to less frequent administration with naproxen, diflunisal and sulindac in rheumatoid arthritis, although there is some evidence of diclofenac's efficacy when administered twice daily, or once daily as a slow release tablet. The drug is also available as suppositories and ampoules for intramuscular injection. No one of the non-steroidal anti-inflammatory agents is the most suitable drug for all patients requiring such therapy, and diclofenac should be considered along with other drugs of its type in the arthritic patient.
双氯芬酸钠是一种苯乙酸衍生物，是一种非甾体抗炎镇痛药，适用于类风湿性关节炎、退行性关节病、强直性脊柱炎及相关病症，以及用于治疗小手术、创伤和痛经引起的疼痛。已发表的数据表明，在类风湿性关节炎中，每日服用双氯芬酸钠75至150毫克（每日3次，每次25至50毫克）与每日服用普通阿司匹林3至5克及每日服用吲哚美辛75至150毫克的疗效相当，在骨关节炎中与吲哚美辛疗效相当。现有数据表明，在骨关节炎患者中，双氯芬酸钠在疗效和耐受性方面与萘普生、布洛芬、舒林酸和二氟尼柳相当。由于口服双氯芬酸一般每日分3次给药，在类风湿性关节炎中，相对于萘普生、二氟尼柳和舒林酸给药频率较低的情况，它可能处于劣势，不过有证据表明每日给药2次或每日服用1次缓释片时双氯芬酸也有疗效。该药物也有栓剂和用于肌肉注射的安瓿剂。对于所有需要此类治疗的患者，没有一种非甾体抗炎药是最合适的药物，在关节炎患者中，双氯芬酸应与其他同类药物一起考虑。
