Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, 119991 Moscow, Russia.
Faculty of Chemistry, National Research University Higher School of Economics, 101000 Moscow, Russia.
Molecules. 2022 Aug 7;27(15):5028. doi: 10.3390/molecules27155028.
A method is proposed for the preparation of stable sols of nanocrystalline cerium dioxide in nonpolar solvents, based on surface modification of CeO nanoparticles obtained by thermal hydrolysis of concentrated aqueous solutions of ammonium cerium(IV) nitrate with residues of 2-ethylhexanoic and octanoic acids. The synthesis was carried out at temperatures below 100 °C and did not require the use of expensive and toxic reagents. An assessment of the radical-scavenging properties of the obtained sols using the superoxide anion-radical neutralization model revealed that they demonstrate notable antioxidant activity. The results obtained indicate the potential of the nanoscale cerium dioxide sols in nonpolar solvents to be used for creating nanobiomaterials possessing antioxidant properties.
提出了一种在非极性溶剂中制备纳米晶二氧化铈稳定溶胶的方法，该方法基于用 2-乙基己酸和辛酸残基对通过浓硝酸铈（IV）铵水溶液热水解得到的 CeO 纳米粒子进行表面改性。该合成在低于 100°C 的温度下进行，并且不需要使用昂贵且有毒的试剂。使用超氧阴离子自由基中和模型评估了所获得的溶胶的清除自由基性能，结果表明它们具有显著的抗氧化活性。所得结果表明，非极性溶剂中纳米二氧化铈溶胶具有作为具有抗氧化性能的纳米生物材料的潜力。
