Ding Yurun, Liu Xiaolin, Zhang Jue, Lv Zhuocheng, Meng Xiangchao, Yuan Zhiguo, Long Teng, Wang You
Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Front Bioeng Biotechnol. 2022 Jul 25;10:947521. doi: 10.3389/fbioe.2022.947521. eCollection 2022.
The treatment of bone defects in weight-bearing areas is mainly to transplant filling materials into the defect area, to provide immediate and strong support for weight-bearing. At present, the commonly used filling material is bone cement, which can only provide physical support without bone regeneration effect. The long-term stress at the interface may cause the loosening of bone cement. The ideal filling material should provide not only strong mechanical support but also promote bone regeneration. We introduce a 3D printing frame-filling structure in this study. The structure was printed with polylactic acid/bioactive glass as the frame, and bone cement as the filler. In this system, bone cement was used to provide immediate fixation, and the frame provided long-term fixation by promoting osteogenic induction and conduction between the interface. The results showed that the degradation of bioactive glass in the frame promoted osteogenic metabolism, induced M2 polarization of macrophages, and inhibited local inflammatory response. The study revealed that implantation of the frame-filling structure significantly promoted bone regeneration in the femoral bone defect area of New Zealand white rabbits. For a bone defect in a weight-bearing area, long-term stability could be obtained by bone integration through this frame-filling structure.
负重部位骨缺损的治疗主要是将填充材料植入缺损区域，为负重提供即时且强大的支撑。目前，常用的填充材料是骨水泥，其仅能提供物理支撑，而无骨再生效果。界面处的长期应力可能导致骨水泥松动。理想的填充材料不仅应提供强大的机械支撑，还应促进骨再生。在本研究中，我们引入了一种3D打印的框架-填充结构。该结构以聚乳酸/生物活性玻璃作为框架进行打印，以骨水泥作为填充物。在这个系统中，骨水泥用于提供即时固定，而框架通过促进界面间的成骨诱导和传导来提供长期固定。结果表明，框架中生物活性玻璃的降解促进了成骨代谢，诱导巨噬细胞向M2极化，并抑制了局部炎症反应。该研究表明，植入框架-填充结构显著促进了新西兰白兔股骨缺损区域的骨再生。对于负重部位的骨缺损，通过这种框架-填充结构实现骨整合可获得长期稳定性。
