Hu Xiangrong, Zhang Li, Lin Qingsong, Zhang Fengkui, Zhao Xin
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Blood Sci. 2022 May 17;4(2):89-92. doi: 10.1097/BS9.0000000000000107. eCollection 2022 Apr.
( is a rare pathogenic fungus, which mainly involves immunocompromised individuals. Here, we report a case of complicated multiple-organ infections involving skin, lungs, and spleen in a 63-year-old female with Evans' syndrome after 9 months of glucocorticoid treatment. Microbial examinations of skin biopsy and blood samples revealed infections. Posaconazole was effective in this patient. During anti-fungi treatment, she developed varicella-zoster virus infection and was diagnosed through next-generation sequencing examination. In conclusion, may affect different organ systems and is susceptible to posaconazole treatment. The molecular-based methods like microbial cell-free DNA sequencing could provide accurate and timely identification of a wide range of infections.
（是一种罕见的致病真菌，主要累及免疫功能低下的个体。在此，我们报告一例63岁患有伊文氏综合征的女性，在接受9个月糖皮质激素治疗后出现皮肤、肺和脾脏复杂多器官感染的病例。皮肤活检和血液样本的微生物检查发现了感染。泊沙康唑对该患者有效。在抗真菌治疗期间，她发生了水痘-带状疱疹病毒感染，并通过下一代测序检查得以确诊。总之，（这种真菌）可能影响不同器官系统，且对泊沙康唑治疗敏感。基于分子的方法如微生物游离DNA测序可为广泛的感染提供准确及时的鉴定。
需注意，原文中部分关键致病真菌名称缺失，我按照格式要求进行了翻译，你可补充完整准确的原文内容以便更精准理解。
