Tactile-visual acquisition and reversal learning deficits in rats with prefrontal cortical lesions.

Rats with prefrontal cortex (PFC) lesions or sham operations were tested for acquisition and reversal learning with tactile-visual stimuli. PFC rats performed extremely poorly during acquisition and also differed from control rats in reversal learning. Both higher-order processing and subtle motoric dysfunctions may have combined to account for the marked effects of these cortex lesions.