Sharma Anusha, Gupta Sarika
Department of Bioscience and Biotechnology Banasthali Vidyapith Banasthali Rajasthan India.
Health Sci Rep. 2022 Aug 10;5(5):e775. doi: 10.1002/hsr2.775. eCollection 2022 Sep.
Fungal dermatophytosis or Tinea is a predominance in about 20%-25% of all total world populations. Dermatophyte infections are mainly caused by fungi belonging to Trichophyton, Epidermophyton, and Microsporum genera along with some other fungi. This epidemiological distribution may change with migration, lifestyle, immunosuppressive state, drug therapy, and socioeconomic conditions.
The present review indicated the bioefficacy of herbal and herbonanoconjugate as safe management of fungal dermatophytic infection.
It also emphasized the action mechanism as fungicidal and fungistatic with different harmful impacts indicating the need for alternative therapeutics. Simultaneously, the herbal and herbonanoconjugate approaches proved better to manage the prevalence of hepatotoxicity, nephrotoxicity, nausea, altered taste, anemia, GI upsets, hair loss, and so forth. due to conventional oral treatment approaches.
Adoption of the remedial approach can be recommended after preclinical trials' approval as a safe treatment.
皮肤癣菌病或癣在全球约20%-25%的总人口中较为常见。皮肤癣菌感染主要由毛癣菌属、表皮癣菌属和小孢子菌属的真菌以及其他一些真菌引起。这种流行病学分布可能会随着移民、生活方式、免疫抑制状态、药物治疗和社会经济状况而改变。
本综述指出了草药及其纳米共轭物对皮肤癣菌感染的安全治疗生物功效。
它还强调了其作为杀菌剂和抑菌剂的作用机制，以及不同的有害影响，这表明需要替代疗法。同时，草药及其纳米共轭物方法在管理肝毒性、肾毒性、恶心、味觉改变、贫血、胃肠道不适、脱发等方面比传统口服治疗方法效果更好。
在临床前试验批准后，可推荐采用这种治疗方法作为一种安全的治疗手段。
