Llewellyn-Smith I J
Experientia. 1987 Jul 15;43(7):813-21. doi: 10.1007/BF01945359.
The discovery of neuropeptides in enteric neurons has revolutionized the study of the microcircuitry of the enteric nervous system. From immunohistochemistry, it is now clear that some individual enteric neurons contain several different neuropeptides with or without other transmitter-specific markers and that these markers occur in various combinations. There is evidence from experiments in which nerve pathways are interrupted that populations of enteric neurons with different combinations of markers have different projection patterns, sending their processes to distinct targets using different routes. Correlations between the neurochemistry of enteric neurons and the types of synaptic inputs they receive are also beginning to emerge from electrophysiological studies. These findings imply that enteric neurons are chemically coded by the combinations of peptides and other transmitter-related substances they contain and that the coding of each population correlates with its role in the neuronal pathways that control gastrointestinal function.
肠道神经元中神经肽的发现彻底改变了对肠神经系统微电路的研究。从免疫组织化学来看，现在很清楚的是，一些单个的肠道神经元含有几种不同的神经肽，有或没有其他递质特异性标记物，并且这些标记物以各种组合形式出现。有实验证据表明，在神经通路被中断的情况下，具有不同标记物组合的肠道神经元群体具有不同的投射模式，它们通过不同的途径将其突起发送到不同的靶标。电生理研究也开始揭示肠道神经元的神经化学与其所接收的突触输入类型之间的相关性。这些发现表明，肠道神经元是由它们所含的肽和其他与递质相关的物质的组合进行化学编码的，并且每个群体的编码与其在控制胃肠功能的神经通路中的作用相关。
