Sjövall H, Jodal M, Lundgren O
Acta Physiol Scand. 1984 Mar;120(3):437-43. doi: 10.1111/j.1748-1716.1984.tb07404.x.
The present study was undertaken to further test the hypothesis of a glucose-induced secretory mechanism in the jejunum of the cat (Sj ovall et al. 1983 b). The experimental design was based on the sodium dependence of active glucose uptake from the intestinal lumen. The rate of glucose uptake from a sodium-free and a sodium-containing perfusate was compared and we also investigated the effect of splanchnic nerve stimulation (SNS) on glucose absorption. The results revealed no difference in "resting" glucose uptake between the two groups. Glucose uptake from the sodium-free solution decreased on SNS whereas no such effect was seen in the sodium-containing segments. These findings can be explained by an SNS evoked inhibition of the glucose induced secretion of sodium from the crypts, which will be rate limiting for glucose uptake when no sodium is present in the perfusate. The findings are thus consistent with the concept of a glucose activated sodium secretion. Data are also presented which indicate that this secretory response is mediated by the enteric nervous system.
本研究旨在进一步验证猫空肠中存在葡萄糖诱导分泌机制的假说（Sj ovall等人，1983年b）。实验设计基于肠道腔内活性葡萄糖摄取对钠的依赖性。比较了无钠灌流液和含钠灌流液中葡萄糖的摄取速率，并且我们还研究了内脏神经刺激（SNS）对葡萄糖吸收的影响。结果显示两组之间“静息”葡萄糖摄取无差异。无钠溶液中的葡萄糖摄取在SNS时减少，而含钠节段未见此效应。这些发现可以通过SNS诱发的隐窝中葡萄糖诱导的钠分泌抑制来解释，当灌流液中不存在钠时，这将成为葡萄糖摄取的限速因素。因此，这些发现与葡萄糖激活钠分泌的概念一致。还提供了数据表明这种分泌反应是由肠神经系统介导的。
