Karimi Zeinab, Chenari Maryam, Rezaie Farhad, Karimi Shima, Parhizgari Najmeh, Mokhtari-Azad Talat
Department of Virology, School of Public Health, Tehran University of Medical Science, Tehran, Iran.
Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran.
Clin Psychopharmacol Neurosci. 2022 May 31;20(2):199-210. doi: 10.9758/cpn.2022.20.2.199.
Depression is one of the most important causes of disability and loss of useful life of people around the world. Acute respiratory infection caused a large number of severe illnesses and deaths of the world and most of these due to viral infections, which is estimated more than 80% of respiratory infections. Detection of viruses by immune pathogen recognition receptors activates the intracellular signaling cascade and eventually cause produces interferons. Inflammatory process begins with secretion of interferons and the expression of interferon-stimulated genes. One of the most important of these genes is indoleamine-pyrrole 2,3-dioxygenase (IDO), which plays a major role in tryptophan catabolism. IDO is an intracellular monomeric enzyme that is also responsible for breaking down and consuming tryptophan in the Kynurenine pathway. Increased inflammation has been linked to decrease tryptophan concentrations and increase kynurenine levels. We tried to explain the role of inflammation by viral respiratory infections in causing depression.
抑郁症是全球范围内导致残疾和人们失去有效生命的最重要原因之一。急性呼吸道感染在全球造成了大量严重疾病和死亡，其中大部分是由病毒感染引起的，据估计，超过80%的呼吸道感染是由病毒引起的。通过免疫病原体识别受体检测病毒会激活细胞内信号级联反应，并最终导致产生干扰素。炎症过程始于干扰素的分泌和干扰素刺激基因的表达。这些基因中最重要的之一是吲哚胺-吡咯2,3-双加氧酶（IDO），它在色氨酸分解代谢中起主要作用。IDO是一种细胞内单体酶，也负责在犬尿氨酸途径中分解和消耗色氨酸。炎症增加与色氨酸浓度降低和犬尿氨酸水平升高有关。我们试图解释病毒性呼吸道感染引起的炎症在导致抑郁症中的作用。
