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Contraction-associated translocation of protein kinase C in rat skeletal muscle.

作者信息

Richter E A, Cleland P J, Rattigan S, Clark M G

出版信息

FEBS Lett. 1987 Jun 15;217(2):232-6. doi: 10.1016/0014-5793(87)80669-5.

Abstract

Electrical stimulation of the sciatic nerve of the anaesthetized rat in vivo led to a time-dependent translocation of protein kinase C from the muscle cytosol to the particulate fraction. Maximum activity of protein kinase C in the particulate fraction occurred after 2 min of intermittent short tetanic contractions of the gastrocnemius-plantaris-soleus muscle group and coincided with the loss of activity from the cytosol. Translocation of protein kinase C may imply a role for this kinase in contraction-initiated changes in muscle metabolism.

摘要

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