心脏手术后输血相关的肾功能障碍：髓样相关蛋白14在中性粒细胞介导的肾小管损伤中的作用。
Transfusion-Related Renal Dysfunction After Cardiac Surgery: The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage.
作者信息
Vourc'h Mickael, Roquilly Antoine, Foucher Adrien, Retiere Christelle, Feuillet Fanny, Devi Sapna, McWilliam Hamish E G, Braudeau Cecile, Bourreille Geraldine, Hachani Abderrahman, O'Kane Dermot, Mueller Scott N, Ischia Joseph, Roussel Jean-Christian, Rigal Jean-Christophe, Josien Regis, Rozec Bertrand, Villadangos Jose A, Asehnoune Karim
机构信息
Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia.
Nantes Université, CHU Nantes, Inserm, Center for Research in Transplantation and Translational Immunology, UMR1064, Nantes, France.
出版信息
JACC Basic Transl Sci. 2022 Jun 1;7(7):627-638. doi: 10.1016/j.jacbts.2022.02.019. eCollection 2022 Jul.
Transfusion is a specific cause of acute kidney injury (AKI) after cardiac surgery. Whether there is an association between the composition of blood products and the onset of AKI is unknown. The present study suggests that the transfusion of packed red blood cells containing a high amount of myeloid-related protein 14 (MRP_14) could increase the incidence of AKI after cardiac surgery. In a mouse model, MRP_14 increased the influx of neutrophils in the kidney after ischemia-reperfusion and their ability to damage tubular cells. Higher concentrations of MRP_14 were found in packed red blood cells from female donors or prepared by whole blood filtration.
输血是心脏手术后急性肾损伤（AKI）的一个特定原因。血液制品的成分与AKI的发生之间是否存在关联尚不清楚。本研究表明，输注含有大量髓系相关蛋白14（MRP_14）的浓缩红细胞会增加心脏手术后AKI的发生率。在小鼠模型中，MRP_14增加了缺血再灌注后肾脏中中性粒细胞的流入及其损伤肾小管细胞的能力。在女性供体的浓缩红细胞或通过全血过滤制备的浓缩红细胞中发现了更高浓度的MRP_14。
Zotero 插件