血浆 S100A8/A9 异二聚体是与心脏手术相关的急性肾损伤的早期预后标志物。
Plasma S100A8/A9 heterodimer is an early prognostic marker of acute kidney injury associated with cardiac surgery.
机构信息
Vascular Biology, Cardiovascular Sciences, National Heart & Lung Institute Division, Faculty of Medicine, Imperial College London, London, SW3 6LY, UK.
National Institute for Health Research Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust, London, SW3 6NP, UK.
出版信息
Biomark Med. 2019 Feb;13(3):205-218. doi: 10.2217/bmm-2018-0238. Epub 2019 Feb 27.
AIM
We investigated whether plasma levels of the inflammation marker S100A8/A9, could predict acute kidney injury (AKI) onset in patients undergoing cardiac surgery necessitating cardiopulmonary bypass (CPB).
PATIENTS & METHODS: Plasma levels of S100A8/A9 and other neutrophil cytosolic proteins were measured in 39 patients pre- and immediately post-CPB.
RESULTS
All markers increased significantly post-CPB with S100A8/A9, S100A12 and myeloperoxidase levels significantly higher in patients who developed AKI within 7 days. S100A8/A9 had good prognostic utility for AKI, with an area under the receiver operating characteristic curve of 0.81 (95% CI: 0.676-0.949) and a cut-off value of 10.6 μg/ml (85.7% sensitivity and 75% specificity) irrespective of age.
CONCLUSION
Plasma S100A8/A9 levels immediately after cardiac surgery, can predict onset of AKI, irrespective of age.
目的
我们研究了炎症标志物 S100A8/A9 的血浆水平是否可以预测需要体外循环（CPB）的心脏手术患者发生急性肾损伤（AKI）。
患者与方法
在 CPB 前和后即刻测量了 39 例患者的 S100A8/A9 和其他中性粒细胞胞质蛋白的血浆水平。
结果
所有标志物在 CPB 后均显著升高，在 7 天内发生 AKI 的患者中 S100A8/A9、S100A12 和髓过氧化物酶水平显著更高。S100A8/A9 对 AKI 具有良好的预后预测能力，其受试者工作特征曲线下面积为 0.81（95%CI：0.676-0.949），截断值为 10.6μg/ml（85.7%的敏感性和 75%的特异性），与年龄无关。
结论
心脏手术后即刻的 S100A8/A9 血浆水平可以预测 AKI 的发生，与年龄无关。
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