Zhang Lei, Yan Congmin, Hou Xun, Zhang Xuhui, Xie Jialin, Xu Hexiang, Tong Yujun, Cui Xinyue, Cai Ke, Pu Xin, Wang Liyan, Bai Tao, Wang Dongwen
Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, China.
First College of Clinical Medicine, Shanxi Medical University, Taiyuan, China.
Transl Androl Urol. 2022 Jul;11(7):974-981. doi: 10.21037/tau-22-414.
The purpose of this study was to investigate the predictive accuracy of erythrocyte count and maximum tumor diameter to maximum kidney diameter ratio (TKR) in patients with renal cell carcinoma (RCC).
We retrospectively analyzed the clinicopathological epidemiological characteristics of patients with RCC in the First Hospital of Shanxi Medical University from 2010 to 2014. Among them, 295 cases with complete follow-up data at the time of visit were selected. We collected data including erythrocyte counts and length of each diameter line of the tumor and kidney. To predict the prognosis of RCC, receiver operating characteristic (ROC) curve analysis was used to calculate the cutoff value of each parameter.
Of the 295 included patients, 199 (67.5%) were male, 96 (32.5%) were female, and the mean (± SD) age was 56.45±11.03 years. The area under the curve (AUC) of the erythrocyte count and the TKR for predicting the prognosis of RCC were 0.672 (SD 0.031; P<0.001) and 0.800 (SD 0.030; P<0.001), respectively. When the cutoff value of the erythrocyte count and TKR count were 3.975 and 0.452, the highest Youden index values were 0.309 and 0.685, and the corresponding sensitivity and specificity were 0.826 and 0.685, and 0.483 and 1.000, respectively.
An erythrocyte count <3.975×10/L and a TKR >0.452 were found to be risk factors for poor prognosis in patients with RCC.
本研究旨在探讨红细胞计数及肿瘤最大直径与患肾最大直径之比（TKR）对肾细胞癌（RCC）患者预后的预测准确性。
回顾性分析山西医科大学第一医院2010年至2014年RCC患者的临床病理流行病学特征。其中，选取就诊时具有完整随访数据的295例患者。收集的数据包括红细胞计数以及肿瘤和肾脏各直径线的长度。为预测RCC的预后，采用受试者工作特征（ROC）曲线分析计算各参数的截断值。
纳入的295例患者中，男性199例（67.5%），女性96例（32.5%），平均（±标准差）年龄为56.45±11.03岁。红细胞计数和TKR预测RCC预后的曲线下面积（AUC）分别为0.672（标准差0.031；P<0.001）和0.800（标准差0.030；P<0.001）。当红细胞计数和TKR计数的截断值分别为3.975和0.452时，约登指数最高值分别为0.309和0.685，相应的敏感性和特异性分别为0.826和0.685，以及0.483和1.000。
红细胞计数<3.975×10/L和TKR>0.452被发现是RCC患者预后不良的危险因素。
