Liang Hongming, Guo Wenyuan, He Honghu, Zhang Hui, Ye Qiongyu, Zhang Qingxin, Liao Jiajia, Shen Yuefei, Wang Jin, Xiao Yousheng, Qin Chao
Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Department of Neurology, The First People's Hospital of Yulin, The Sixth Affiliated Hospital of Guangxi Medical University, Yulin, China.
Front Neurosci. 2022 Jul 26;16:894454. doi: 10.3389/fnins.2022.894454. eCollection 2022.
Recently, the neurite outgrowth inhibitor-B (Nogo-B) receptor has been reported as a novel candidate gene for Parkinson's disease (PD). Nogo-B receptors need to combine with soluble Nogo-B to exert their physiological function. However, little is known about the relationship between serum soluble Nogo-B and PD.
Serum levels of sNogo-B and α-Synuclein (α-Syn) were measured in a cohort of 53 patients with PD and 49 healthy controls with the ELISA kit method.
Serum sNogo-B level is significantly lower in the PD group than that in healthy controls and is negatively correlated with UPDRS-III score ( = 0.049), H&Y stage ( = 0.0108) as well as serum α-Syn level ( = 0.0001). The area under the curve (AUC) of serum sNogo-B in differentiating patients with PD from controls was 0.801 while the AUC of serum α-Syn was 0.93. Combining serum sNogo-B and α-Syn in differentiating patients with PD from HC presented higher discriminatory potential (AUC = 0.9534).
Decreased serum sNogo-B may be a potential biomarker for PD. Lower Nogo-B level reflects worse motor function and disease progression of PD. Serum sNogo-B is of added value to serum α-Syn panel in distinguishing PD from controls. Future studies are needed to confirm in larger samples and different populations.
最近，神经突生长抑制因子B（Nogo-B）受体被报道为帕金森病（PD）的一个新的候选基因。Nogo-B受体需要与可溶性Nogo-B结合才能发挥其生理功能。然而，关于血清可溶性Nogo-B与PD之间的关系知之甚少。
采用酶联免疫吸附测定试剂盒法，检测了53例PD患者和49例健康对照者血清中可溶性Nogo-B（sNogo-B）和α-突触核蛋白（α-Syn）的水平。
PD组血清sNogo-B水平显著低于健康对照组，且与统一帕金森病评定量表第三部分（UPDRS-III）评分（r = 0.049）、 Hoehn和Yahr分期（r = 0.0108）以及血清α-Syn水平（r = 0.0001）呈负相关。血清sNogo-B区分PD患者与对照组的曲线下面积（AUC）为0.801，而血清α-Syn的AUC为0.93。联合血清sNogo-B和α-Syn区分PD患者与健康对照者具有更高的鉴别潜力（AUC = 0.9534）。
血清sNogo-B降低可能是PD的一个潜在生物标志物。较低的Nogo-B水平反映了PD患者较差的运动功能和疾病进展。血清sNogo-B在区分PD与对照组方面对血清α-Syn检测具有附加价值。未来需要在更大样本和不同人群中进行研究以证实。
