Artificial Liver Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
PeerJ. 2022 Aug 5;10:e13828. doi: 10.7717/peerj.13828. eCollection 2022.
The gender differences in demographic and clinical characteristics were examined in patients with hepatitis B virus (HBV)-related liver diseases.
Overall, 634 patients (44.7 ± 13.8 years) were consecutively included. Data of demographic and clinical characteristics were collected during an assessment interview. Comparisons between male and female patients in terms of demographic and clinical data were carried out using univariate analyses. The independent associations between the demographic and clinical variables and gender were examined with either logistic regression or analysis of covariance as appropriate.
The study sample consisted of 452 male and 182 female patients. Multiple logistic regression analyses revealed that being employed (OR = 3.4), personal monthly income <3,000 yuan (OR = 0.3), being current alcohol users (OR = 6.4), Cirrhosis (OR = 5.9), Hepatocellular Carcinoma (HCC) (OR = 8.5) and having less severe insomnia (OR = 0.6) were independently associated with male gender. The analysis of covariance revealed that after controlling for other potential confounding variables, later onset of HBV-related diseases ( = 4.5, = 0.03) and older age ( = 6.7, = 0.009) were independently associated with male gender.
Given the significant clinical differences in male and female patients with HBV-related liver diseases, more attention should be given to gender-specific treatment and prevention for this population.
本研究旨在探讨乙型肝炎病毒（HBV）相关肝病患者的人口统计学和临床特征的性别差异。
共连续纳入 634 例患者（44.7±13.8 岁）。在评估访谈期间收集人口统计学和临床特征数据。使用单因素分析比较男女患者的人口统计学和临床数据。使用逻辑回归或协方差分析适当检查人口统计学和临床变量与性别之间的独立关联。
研究样本包括 452 名男性和 182 名女性患者。多因素逻辑回归分析显示，在职（OR=3.4）、个人月收入<3000 元（OR=0.3）、当前饮酒者（OR=6.4）、肝硬化（OR=5.9）、肝细胞癌（HCC）（OR=8.5）和失眠程度较轻（OR=0.6）与男性性别独立相关。协方差分析显示，在控制其他潜在混杂变量后，HBV 相关疾病的发病年龄较晚（β=4.5，P=0.03）和年龄较大（β=6.7，P=0.009）与男性性别独立相关。
鉴于男性和女性 HBV 相关肝病患者的临床差异显著，应更加关注该人群的性别特异性治疗和预防。
