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胃旁路手术后粪便总 IgA 水平升高，天然 IgM 抗体减少。

Total fecal IgA levels increase and natural IgM antibodies decrease after gastric bypass surgery.

机构信息

Medical Microbiology and Immunology, Research Unit of Biomedicine, University of Oulu, Oulu, Finland.

Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.

出版信息

APMIS. 2022 Nov;130(11):637-646. doi: 10.1111/apm.13268. Epub 2022 Aug 26.

DOI:10.1111/apm.13268
PMID:35959517
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9805076/
Abstract

Obesity is associated with low-grade inflammation and increased systemic oxidative stress. Roux-en-Y gastric bypass (RYGB) surgery is known to ameliorate the obesity-induced metabolic dysfunctions. We aimed to study the levels of natural antibodies in feces, before and 6 months after RYGB surgery in obese individuals with and without type 2 diabetes (T2D). Sixteen individuals with T2D and 14 non-diabetic (ND) individuals were operated. Total IgA, IgG and IgM antibody levels and specific antibodies to oxidized low-density lipoprotein (oxLDL), malondialdehyde-acetaldehyde adducts (MAA adducts), Porphyromonas gingivalis gingipain A hemagglutinin domain (Rgp44) and phosphocholine (PCho) were measured using chemiluminescence immunoassay. Total fecal IgA was elevated, while total IgM and IgG were not affected by the surgery. Fecal natural IgM specific to oxLDL decreased significantly in both T2D and ND individuals, while fecal IgM to Rgp44 and PCho decreased significantly in T2D individuals. A decrease in IgG to MAA-LDL, Rgp44 and PCho was detected. RYGB surgery increases the levels of total fecal IgA and decreases fecal natural IgG and IgM antibodies specific to oxLDL. Natural antibodies and IgA are important in maintaining the normal gut homeostasis and first-line defense against microbes, and their production is markedly altered with RYGB surgery.

摘要

肥胖与低度炎症和全身性氧化应激增加有关。Roux-en-Y 胃旁路（RYGB）手术已知可改善肥胖引起的代谢功能障碍。我们旨在研究 2 型糖尿病（T2D）和非 2 型糖尿病（ND）肥胖个体在 RYGB 手术前后粪便中天然抗体的水平。对 16 名 T2D 患者和 14 名非糖尿病（ND）个体进行了手术。使用化学发光免疫测定法测量总 IgA、IgG 和 IgM 抗体水平以及针对氧化低密度脂蛋白（oxLDL）、丙二醛-乙醛加合物（MAA 加合物）、牙龈卟啉单胞菌牙龈蛋白酶 A 血凝素结构域（Rgp44）和磷酸胆碱（PCho）的特异性抗体。手术对总粪便 IgA 有升高作用，但对总 IgM 和 IgG 没有影响。在 T2D 和 ND 个体中，粪便天然 IgM 对 oxLDL 的特异性显著降低，而 T2D 个体中粪便 IgM 对 Rgp44 和 PCho 的特异性显著降低。检测到 IgG 对 MAA-LDL、Rgp44 和 PCho 的减少。RYGB 手术增加总粪便 IgA 的水平，并降低粪便中针对 oxLDL 的天然 IgG 和 IgM 抗体。天然抗体和 IgA 对于维持正常的肠道内稳态和对抗微生物的第一道防线非常重要，并且它们的产生在 RYGB 手术后明显改变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/826a/9805076/bf1fa48f0ee5/APM-130-637-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/826a/9805076/0eab97e2b38e/APM-130-637-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/826a/9805076/34902733ee55/APM-130-637-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/826a/9805076/bf1fa48f0ee5/APM-130-637-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/826a/9805076/0eab97e2b38e/APM-130-637-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/826a/9805076/34902733ee55/APM-130-637-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/826a/9805076/bf1fa48f0ee5/APM-130-637-g003.jpg

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