College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
Qingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, China.
Mini Rev Med Chem. 2023;23(3):361-377. doi: 10.2174/1389557522666220811123115.
The human gut is a complex but stable micro-ecosystem in which the intestinal microbiota play a key role in human health, the health of the intestine and also affect the ability of the host to metabolize nutrients. Intestinal microbiota can affect human physiological functions by regulating host metabolism, immunity and intestinal barrier function. Dysbiosis in the intestinal microbiota is a crucial stimulus for the development of various diseases, which is associated with a variety of diseases in the body. The composition and function of intestinal microbiota depend on the host's physiological status, genetic makeup, dietary habits, age, and environment, which are the risk factors for obesity, diabetes, cardiovascular diseases and tumors. Polyphenols are important plant secondary metabolites with many physiological functions like anti-oxidation, antitumor, bacteriostasis, cardiovascular and cerebrovascular prevention, and protection of liver and kidney and so on. A large number of studies have confirmed the benefits of dietary polyphenols to human health. Polyphenols and their associated metabolites affect intestinal health and the balance of intestinal microbiota by stimulating the growth of beneficial bacteria and inhibiting the proliferation of pathogens. This review aims to update the current knowledge and highlight how the bioactivities of polyphenols can modulate the intestinal microbiota and regulate the mechanisms of the microbiota, providing a theoretical basis and reference for the scientific and overall use of polyphenols to prevent and treat intestinal diseases and maintain human intestinal health.
人类肠道是一个复杂但稳定的微生态系统，其中肠道微生物群在人类健康、肠道健康以及影响宿主代谢营养物质的能力方面发挥着关键作用。肠道微生物群可以通过调节宿主代谢、免疫和肠道屏障功能来影响人类的生理功能。肠道微生物群的失调是各种疾病发展的关键刺激因素，与体内的各种疾病有关。肠道微生物群的组成和功能取决于宿主的生理状态、遗传构成、饮食习惯、年龄和环境，这些都是肥胖症、糖尿病、心血管疾病和肿瘤的风险因素。多酚是具有多种生理功能的重要植物次生代谢物，如抗氧化、抗肿瘤、抑菌、心脑血管预防、肝肾保护等。大量研究证实了膳食多酚对人类健康的益处。多酚及其相关代谢物通过刺激有益菌的生长和抑制病原体的增殖来影响肠道健康和肠道微生物群的平衡。本综述旨在更新目前的知识，并强调多酚的生物活性如何调节肠道微生物群和调节微生物群的机制，为多酚预防和治疗肠道疾病和维持人类肠道健康的科学和全面应用提供理论依据和参考。
