Department of Biosciences, Rajagiri College of Social Sciences, Kalamaserry, Kochi, India.
Nepal Jesuit Society, St. Xavier's College, Jawalakhel, Lalitpur Dt. Kathmandu, Nepal.
Crit Rev Food Sci Nutr. 2024;64(2):280-310. doi: 10.1080/10408398.2022.2106179. Epub 2022 Aug 12.
Ellagitannins are vital bioactive polyphenols that are widely distributed in a variety of plant-based foods. The main metabolites of ellagitannins are urolithins, and current research suggests that urolithins provide a variety of health benefits. This review focused on the role of the gut bacteria in the conversion of ellagitannins to urolithins. Based on the results of in vitro and in vivo studies, the health benefits of urolithins, including antioxidant, anti-inflammatory, anti-cancer, anti-obesity, anti-diabetic, anti-aging, cardiovascular protective, neuroprotective, kidney protective, and muscle mass protective effects, were thoroughly outlined, with a focus on their associated molecular mechanisms. Finally, we briefly commented on urolithins' safety. Overall, urolithins' diverse health benefits indicate the potential utilization of ellagitannins and urolithins in the creation of functional foods and nutraceuticals to treat and prevent some chronic diseases.
鞣花单宁是重要的生物活性多酚，广泛存在于各种植物性食物中。鞣花单宁的主要代谢物是尿石素，目前的研究表明，尿石素有多种健康益处。本综述重点介绍了肠道细菌在鞣花单宁转化为尿石素中的作用。根据体外和体内研究的结果，全面阐述了尿石素的健康益处，包括抗氧化、抗炎、抗癌、抗肥胖、抗糖尿病、抗衰老、心血管保护、神经保护、肾脏保护和肌肉质量保护作用，并重点介绍了其相关的分子机制。最后，我们简要讨论了尿石素的安全性。总的来说，尿石素的多种健康益处表明，鞣花单宁和尿石素具有在功能性食品和营养保健品中的潜在应用价值，可用于治疗和预防一些慢性疾病。
