Ribeiro Marcia, Alvarenga Livia, Cardozo Ludmila F M F, Baptista Beatriz G, Nascimento Danielle, Esgalhado Marta, Mafra Denise
Graduate Program in Biological Sciences - Physiology, IBCCF, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro (RJ), Brazil.
Unidade de Pesquisa Clínica-UPC, Rua Marquês de Paraná, 303/4 Andar, Niterói, RJ, Brazil.
Curr Nutr Rep. 2025 Apr 3;14(1):55. doi: 10.1007/s13668-025-00645-0.
This narrative review investigates how urolithins produced by the gut microbiota can regulate transcription factors (such as NRF2, NF-kB, and PPAR-γ) associated with senescence, inflammation, and imbalanced redox status. It also discusses the potential benefits of urolithins for patients with chronic diseases, including cardiovascular disease, cancer, diabetes, obesity, and chronic kidney disease.
Studies have shown that urolithins have many health benefits, including anti-inflammatory, antioxidant, antimicrobial, and anti-atherosclerotic effects. They are also linked to improved mitochondrial function and imbalanced redox associated with activating the Nrf2/ARE pathway. Urolithins are metabolites produced by gut microbiota from ellagic acid and ellagitannins, polyphenols primarily found in nuts and fruits, including pomegranates and berries like raspberries, cloudberries, and blackberries.
本叙述性综述探讨肠道微生物群产生的尿石素如何调节与衰老、炎症和氧化还原状态失衡相关的转录因子（如NRF2、NF-κB和PPAR-γ）。还讨论了尿石素对患有慢性疾病（包括心血管疾病、癌症、糖尿病、肥胖症和慢性肾病）患者的潜在益处。
研究表明，尿石素有许多健康益处，包括抗炎、抗氧化、抗菌和抗动脉粥样硬化作用。它们还与改善线粒体功能以及激活Nrf2/ARE途径相关的氧化还原失衡有关。尿石素是肠道微生物群从鞣花酸和鞣花单宁产生的代谢产物，鞣花酸和鞣花单宁是主要存在于坚果和水果（包括石榴以及树莓、云莓和黑莓等浆果）中的多酚。
