From the Pró-Rim Foundation, Joinville, Santa Catarina, Brazil (Dr Nerbass, Dr Vieira); Division of Nephrology, Department of Medicine, Schulich School of Medicine, London, Ontario, Canada (Dr Moist); Kidney Clinical Research Unit, London Health Service Center, London, Ontario, Canada (Dr Moist); School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil (Dr Pecoits-Filho); Arbor Research Collaborative for Health, Ann Arbor, Michigan (Dr Pecoits-Filho).
J Occup Environ Med. 2022 Nov 1;64(11):e685-e689. doi: 10.1097/JOM.0000000000002666. Epub 2022 Aug 16.
The aims of the study are to re-evaluate kidney function in workers exposed and not exposed to heat stress after 2 years and to compare kidney function cross-shift using creatinine and cystatin C.
Participants were workers from a metallurgical industry. The clinical and biochemical markers of hydration and kidney function were evaluated before and after a single shift in work.
We included 14 workers (6 in the heat group and 8 in the control group). The serum creatinine levels did not change during the follow-up period. Cross-shift, creatinine-based eGFR (estimated glomerular filtration rate) decreased, and cystatin C-based eGFR was maintained in the heat and control groups.
Workers exposed to heat stress maintained their kidney function after a 2-year follow-up. Cystatin C is a better kidney function marker than creatinine for cross-shift assessments in this setting.
本研究旨在对接触和不接触热应激的工人在暴露 2 年后的肾功能进行重新评估，并使用肌酐和胱抑素 C 比较跨班次的肾功能。
参与者为冶金行业的工人。在单次轮班前后评估了水合和肾功能的临床和生化标志物。
我们纳入了 14 名工人（热组 6 人，对照组 8 人）。随访期间血清肌酐水平没有变化。在热组和对照组，基于肌酐的 eGFR（估算肾小球滤过率）在跨班次时下降，而基于胱抑素 C 的 eGFR 保持不变。
暴露于热应激的工人在 2 年的随访后保持了肾功能。在这种情况下，胱抑素 C 比肌酐更适合用于跨班次评估肾功能。
