自闭症与典型发育儿童听觉皮层活动的差异成熟。
Differential Maturation of Auditory Cortex Activity in Young Children with Autism and Typical Development.
机构信息
Lurie Family Foundations MEG Imaging Center, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
出版信息
J Autism Dev Disord. 2023 Oct;53(10):4076-4089. doi: 10.1007/s10803-022-05696-8. Epub 2022 Aug 12.
Maturation of auditory cortex neural encoding processes was assessed in children with typical development (TD) and autism. Children 6-9 years old were enrolled at Time 1 (T1), with follow-up data obtained ~ 18 months later at Time 2 (T2), and ~ 36 months later at Time 3 (T3). Findings suggested an initial period of rapid auditory cortex maturation in autism, earlier than TD (prior to and surrounding the T1 exam), followed by a period of faster maturation in TD than autism (T1-T3). As a result of group maturation differences, post-stimulus group differences were observed at T1 but not T3. In contrast, stronger pre-stimulus activity in autism than TD was found at all time points, indicating this brain measure is stable across time.
听觉皮层神经编码过程的成熟度在具有典型发育（TD）和自闭症的儿童中进行了评估。6-9 岁的儿童在时间 1（T1）入组，在大约 18 个月后的时间 2（T2）和大约 36 个月后的时间 3（T3）获得了随访数据。研究结果表明，自闭症的听觉皮层成熟有一个初始的快速阶段，早于 TD（在 T1 检查之前和期间），随后是 TD 比自闭症更快的成熟阶段（T1-T3）。由于组间成熟差异，在 T1 时观察到刺激后组间差异，但在 T3 时未观察到。相比之下，在所有时间点都发现自闭症的预刺激活动强于 TD，表明该脑测量在整个时间内是稳定的。
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