Lurie Family Foundations MEG Imaging Center, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
J Autism Dev Disord. 2023 Oct;53(10):4076-4089. doi: 10.1007/s10803-022-05696-8. Epub 2022 Aug 12.
Maturation of auditory cortex neural encoding processes was assessed in children with typical development (TD) and autism. Children 6-9 years old were enrolled at Time 1 (T1), with follow-up data obtained ~ 18 months later at Time 2 (T2), and ~ 36 months later at Time 3 (T3). Findings suggested an initial period of rapid auditory cortex maturation in autism, earlier than TD (prior to and surrounding the T1 exam), followed by a period of faster maturation in TD than autism (T1-T3). As a result of group maturation differences, post-stimulus group differences were observed at T1 but not T3. In contrast, stronger pre-stimulus activity in autism than TD was found at all time points, indicating this brain measure is stable across time.
听觉皮层神经编码过程的成熟度在具有典型发育（TD）和自闭症的儿童中进行了评估。6-9 岁的儿童在时间 1（T1）入组，在大约 18 个月后的时间 2（T2）和大约 36 个月后的时间 3（T3）获得了随访数据。研究结果表明，自闭症的听觉皮层成熟有一个初始的快速阶段，早于 TD（在 T1 检查之前和期间），随后是 TD 比自闭症更快的成熟阶段（T1-T3）。由于组间成熟差异，在 T1 时观察到刺激后组间差异，但在 T3 时未观察到。相比之下，在所有时间点都发现自闭症的预刺激活动强于 TD，表明该脑测量在整个时间内是稳定的。
