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异常的听觉系统及其对自闭症的发育意义。

Aberrant auditory system and its developmental implications for autism.

机构信息

Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, China; School of Psychology, Center for Studies of Psychological Application, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, 510631, China.

Autism Research Center, South China Normal University, Guangzhou, 510631, China.

出版信息

Sci China Life Sci. 2021 Jun;64(6):861-878. doi: 10.1007/s11427-020-1863-6. Epub 2021 Jan 22.

Abstract

Most infants who are later diagnosed with autism show delayed speech and language and/or atypical language profile. There is a large body of research on abnormal speech and language in children with autism. However, auditory development has been relatively under-investigated in autism research, despite its inextricable relationship with language development and despite researchers' ability to detect abnormalities in brain development and behavior in early infancy. In this review, we synthesize research on auditory processing in the prenatal period through infancy and childhood in typically developing children, children at high risk for autism, and children diagnosed with autism. We conclude that there are clear neurobiological and behavioral links between abnormal auditory development and the deficits in social communication seen in autism. We then offer perspectives on the need for a systematic characterization of early auditory development in autism, and identified questions to be addressed in future research on the development of autism.

摘要

大多数后来被诊断为自闭症的婴儿都有语言发育迟缓,和/或语言模式异常。自闭症儿童的异常语言已有大量研究。但是,尽管听觉发展与语言发展密切相关,并且研究人员能够在婴儿期早期检测到大脑发育和行为的异常,自闭症研究中对听觉发展的研究仍相对较少。在这篇综述中,我们综合了正常发育儿童、自闭症高风险儿童和自闭症儿童在产前到婴幼儿期的听觉处理研究。我们得出结论,异常的听觉发展与自闭症患者的社会交流缺陷之间存在明显的神经生物学和行为联系。我们还探讨了自闭症中进行早期听觉发展系统特征描述的必要性,并确定了未来自闭症发展研究中需要解决的问题。

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