MUM Genomics Facility, Monash University Malaysia, 47500, Bandar Sunway, Selangor Darul Ehsan, Malaysia.
TropMed and Biology Multidisciplinary Platform, Monash University Malaysia, 47500, Bandar Sunway, Selangor, Malaysia.
Sci Rep. 2022 Aug 12;12(1):13743. doi: 10.1038/s41598-022-17884-8.
Southeast Asia comprises 11 countries that span mainland Asia across to numerous islands that stretch from the Andaman Sea to the South China Sea and Indian Ocean. This region harbors an impressive diversity of history, culture, religion and biology. Indigenous people of Malaysia display substantial phenotypic, linguistic, and anthropological diversity. Despite this remarkable diversity which has been documented for centuries, the genetic history and structure of indigenous Malaysians remain under-studied. To have a better understanding about the genetic history of these people, especially Malaysian Negritos, we sequenced whole genomes of 15 individuals belonging to five indigenous groups from Peninsular Malaysia and one from North Borneo to high coverage (30X). Our results demonstrate that indigenous populations of Malaysia are genetically close to East Asian populations. We show that present-day Malaysian Negritos can be modeled as an admixture of ancient Hoabinhian hunter-gatherers and Neolithic farmers. We observe gene flow from South Asian populations into the Malaysian indigenous groups, but not into Dusun of North Borneo. Our study proposes that Malaysian indigenous people originated from at least three distinct ancestral populations related to the Hoabinhian hunter-gatherers, Neolithic farmers and Austronesian speakers.
东南亚由 11 个国家组成，跨越亚洲大陆，延伸至安达曼海至南海和印度洋的众多岛屿。该地区拥有令人印象深刻的历史、文化、宗教和生物多样性。马来西亚的土著人民表现出显著的表型、语言和人类学多样性。尽管这种多样性已经被记录了几个世纪，但马来西亚土著人的遗传历史和结构仍然研究不足。为了更好地了解这些人的遗传历史，特别是马来西亚尼格利陀人，我们对来自马来西亚半岛的五个土著群体和来自北婆罗洲的一个群体的 15 个人进行了全基因组测序，覆盖率高达 30X。我们的结果表明，马来西亚的土著人口在遗传上与东亚人口密切相关。我们表明，现代马来西亚尼格利陀人可以被模拟为古老的和巴亨山人狩猎采集者和新石器时代农民的混合体。我们观察到南亚人群向马来西亚土著群体的基因流动，但没有向北婆罗洲的杜顺群体流动。我们的研究表明，马来西亚土著人至少起源于三个不同的祖先群体，与和巴亨山人狩猎采集者、新石器时代农民和南岛语族有关。
